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The Role of ALDH2 in Sepsis and the To-Be-Discovered Mechanisms

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Aldehyde Dehydrogenases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1193))

Abstract

Sepsis, defined as life-threatening tissue damage and organ dysfunction caused by a dysregulated host response to infection, is a critical disease which imposes global health burden. Sepsis-induced organ dysfunction, including circulatory and cardiac dysfunction, hepatic dysfunction, renal dysfunction, etc., contributes to high mortality and long-term disability of sepsis patients. Altered inflammatory response, ROS and reactive aldehyde stress, mitochondrial dysfunction, and programmed cell death pathways (necrosis, apoptosis, and autophagy) have been demonstrated to play crucial roles in septic organ dysfunction. Unfortunately, except for infection control and supportive therapies, no specific therapy exists for sepsis. New specific therapeutic targets are highly warranted. Emerging studies suggested a role of potential therapeutic target of ALDH2, a tetrameric enzyme located in mitochondria to detoxify aldehydes, in septic organ dysfunction. In this article, we will review the presentations and pathophysiology of septic organ dysfunction, as well as summarize and discuss the recent insights regarding ALDH2 in sepsis.

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Acknowledgment

This study was supported by the National Natural Science Foundation of China (81570401, 81772036, 81571934, 81671952, 81873950, 81873953, 81701952), National Key R&D Program of China (2017YFC0908700, 2017YFC0908703), Taishan Scholar Program of Shandong Province (ts20130911), Taishan Young Scholar Program of Shandong Province (tsqn20161065), Key R&D Program of Shandong Province (2016GSF201235, 2016ZDJS07A14, 2018GSF118003), and the Fundamental Research Funds of Shandong University (2014QLKY04, 2018JC011).

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Authors and Affiliations

  1. Department of Emergency Medicine and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China

    Jiaojiao Pang, Yue Zheng, Qi Han, Ying Zhang, Ruru Sun, Jiali Wang, Feng Xu & Yuguo Chen

  2. Clinical Research Center for Emergency and Critical Care Medicine of Shandong Province, Institute of Emergency and Critical Care Medicine of Shandong University, Qilu Hospital of Shandong University, Jinan, China

    Jiaojiao Pang, Yue Zheng, Qi Han, Ying Zhang, Ruru Sun, Jiali Wang, Feng Xu & Yuguo Chen

  3. Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Qilu Hospital of Shandong University, Jinan, China

    Jiaojiao Pang, Yue Zheng, Qi Han, Ying Zhang, Ruru Sun, Jiali Wang, Feng Xu & Yuguo Chen

  4. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, China

    Jiaojiao Pang, Yue Zheng, Qi Han, Ying Zhang, Ruru Sun, Jiali Wang, Feng Xu & Yuguo Chen

  5. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

    Yingmei Zhang & Jun Ren

  6. Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY, USA

    Yingmei Zhang & Jun Ren

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  1. Jiaojiao Pang
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  2. Yue Zheng
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  3. Qi Han
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  4. Ying Zhang
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  7. Feng Xu
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  8. Yingmei Zhang
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  9. Jun Ren
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  10. Yuguo Chen
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Correspondence to Jun Ren or Yuguo Chen .

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Editors and Affiliations

  1. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

    Jun Ren

  2. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

    Yingmei Zhang

  3. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

    Junbo Ge

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Pang, J. et al. (2019). The Role of ALDH2 in Sepsis and the To-Be-Discovered Mechanisms. In: Ren, J., Zhang, Y., Ge, J. (eds) Aldehyde Dehydrogenases. Advances in Experimental Medicine and Biology, vol 1193. Springer, Singapore. https://doi.org/10.1007/978-981-13-6260-6_10

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