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  • © 2019

Aldehyde Dehydrogenases

From Alcohol Metabolism to Human Health and Precision Medicine

  • Covers the science of ALDH enzymes in relation to chronic disease processes
  • Provides the future therapeutic potentials of targeting ALDH
  • Demonstrates the unique value of targeting genetic polymorphism in ALDH enzymes in personalized medicine

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1193)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xx
  2. Role of Alcohol Oxidative Metabolism in Its Cardiovascular and Autonomic Effects

    • Mahmoud M. El-Mas, Abdel A. Abdel-Rahman
    Pages 1-33
  3. Environmental Aldehyde Sources and the Health Implications of Exposure

    • Pritam Sinharoy, Stacy L. McAllister, Megana Vasu, Eric R. Gross
    Pages 35-52
  4. ALDH2 and Cardiovascular Disease

    • Che-Hong Chen, Julio C. B. Ferreira, Daria Mochly-Rosen
    Pages 53-67
  5. Aldehyde Dehydrogenase 2 and Heart Failure

    • Wenjia Li, Cheng Shen, Lei Yin, Junbo Ge, Aijun Sun
    Pages 89-106
  6. Aldehyde Dehydrogenase (ALDH) 2 in Diabetic Heart Diseases

    • Srikar Munukutla, Guodong Pan, Suresh S. Palaniyandi
    Pages 155-174
  7. The Role of ALDH2 in Sepsis and the To-Be-Discovered Mechanisms

    • Jiaojiao Pang, Yue Zheng, Qi Han, Ying Zhang, Ruru Sun, Jiali Wang et al.
    Pages 175-194
  8. ALDH2 and Stroke: A Systematic Review of the Evidence

    • Haixia Xu, Yingmei Zhang, Jun Ren
    Pages 195-210
  9. ALDH2 and Cancer Therapy

    • Li-Shun Wang, Zhao-Xia Wu
    Pages 221-228

About this book

This volume covers the science of ALDH enzymes in relation to chronic disease processes and the future therapeutic potentials of targeting ALDH in these processes. It thoroughly reviews the roles of ALDH family in alcohol metabolism, as well as recent findings of their emerging roles in a variety of human pathologies such as cardiovascular diseases, diabetes, obesity, stroke, cancer, liver diseases and kidney diseases. Delicate contribution of ALDH enzymes in the therapeutics against chronic diseases is also discussed. It demonstrates the unique value of targeting genetic polymorphism in ALDH enzymes in personalized medicine. The book will appeal to scientists, physicians, graduate and professional students in the fields of ALDH enzymes, alcohol metabolism, cardiometabolic and other chronic diseases. Pharmaceutical and other companies developing new tools for cardiometabolic and chronic diseases treatment will also find this a valuable resource.


Editors and Affiliations

  • Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

    Jun Ren, Yingmei Zhang, Junbo Ge

About the editors

Prof. Jun Ren is Professor at the Department of Cardiology, Zhongshan Hospital, Fudan University, China, and Associate Dean for Research & Professor of Pharmacology, University of Wyoming College of Health Sciences, USA.
Prof. Yingmei Zhang is Professor at the Department of Cardiology, Zhongshan Hospital, Fudan University, China.
Prof. Junbo Ge is an Academician of the Chinese Academy of Sciences, and Professor at the Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institute of Panvascular Medicine, Fudan University, Shanghai, China.

Bibliographic Information

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access