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Recent Antibiotics Used in Dental Disease Management

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Abstract

This chapter considers the changes in antibiotic usage in dentistry over the recent past. We have done an insilico comparative analysis of the effectiveness of commercial antibiotics Chlorhexidine, with a natural compounds Macelignan and eugenol against Streptococcus mutans, a dental carries causing bacteria. Treatment and prophylaxis with antibiotics are inevitable for oral care. Antibiotics are used when there is clinical evidence of local infection or systemic sepsis. First-line antibiotics like amoxicillin, phenoxymethylpenicillin, metronidazole and erythromycin are prescribed, as penicillin still remains the gold standard. Since these commercial antibiotics are causing many side effects, we have undertaken this comparative study with the commercial antibiotics and the results revealed that the binding energy levels and affinity of towards the adhesion protein ligand of Streptococcus mutans and the compound Macelignan were considerably equal with the commercial disinfectant Chlorhexidine. The second natural compound eugenol present in cloves could also able to bind with the target protein. Hence the dentists should consider to prescribe these natural compounds instead of the semisynthetic antibiotics which are causing side effects.

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References

  • (ADA) American dental association (2017) Antibiotic prophylaxis prior to dental procedures. Available at: http://www.ada.org/en/member-center/oral-health-topics/antibiotic-prophylaxis

  • Adell R, Lekholm U, Branemark PI (1985) Surgical procedures. In: Branemark PI, Zarb GA, Albrektsson T (eds) Tissue-integrated prostheses. Quintessence Publishing Co, Chicago, pp 211–232

    Google Scholar 

  • Ahn S, Cho E, Kim H, Park S, Lim Y, Kook J (2012) The antimicrobial effects of deglycyrrhizinated licorice root extract on Streptococcus mutans UA159 in both planktonic and biofilm cultures. Anaerobe 18(6):590–596

    Article  CAS  Google Scholar 

  • Awano S, Ansai T, Takata Y, Soh I, Akifusa S, Hamasaki T, Yoshida A, Sonoki K, Fujisawa K, Takehara T (2008) Oral health and mortality risk from pneumonia in the elderly. J Dent Res 87:334–339

    Article  CAS  Google Scholar 

  • Baddour LM, Bettman MA, Bolger AF, Bolger A, Ferrieri P (2003) Nonvalvular cardiovascular device-related infections. Circulation 108(16):2015–2031

    Article  Google Scholar 

  • Bae K, Jun EJ, Lee SM, Paik DI, Kim JB (2006) Effect of water-soluble reduced chitosan on Streptococcus mutans, plaque regrowth and biofilm vitality. Clin Oral Investig 10:102–107

    Article  CAS  Google Scholar 

  • Beck JD, Offenbacher S (2005) Systemic effects of periodontitis: epidemiology of periodontal disease and cardiovascular disease. J Periodontol 76:2089–2100

    Article  Google Scholar 

  • Belkaid Y, Hand TW (2014) Role of the microbiota in immunity and inflammation. Cell 157(1):121–141

    Article  CAS  Google Scholar 

  • Busscher HJ, Engels E, Dijkstra RJ, van der Mei HC (2008) Influence of a chitosan on oral bacterial adhesion and growth in vitro. Eur J Oral Sci 116:493–495

    Article  Google Scholar 

  • Carson CF, Hammer KA, Riley TV (2006) Melaleuca alternifolia (tea tree) oil: a review of antimicrobial and other medicinal properties. Clin Microbiol Rev 19(1):50–62

    Article  CAS  Google Scholar 

  • CDC (2014) Antibiotic/antimicrobial resistance. About anti-microbial resistance: a brief overview. Available at: http://www.cdc.gov/drugresistance/about.html

  • Choi BK, Kim KY, Yoo YJ, SJ O, Choi JH, Kim CY (2001) In vitro antimicrobial activity of a chitooligosaccharide mixture against Actinobacillus actinomycetemcomitans and Streptococcus mutans. Int J Antimicrob Agents 18:553–557

    Article  CAS  Google Scholar 

  • Cope A, Francis N, Wood F, Mann MK, Chestnutt IG (2014) Cochrane database of systematic reviews. Wiley. ISSN 1465-1858

    Google Scholar 

  • Costerton JW (1999). Introduction to biofilm. Int J Antimicrob Agents; 11:217–221; discussion 237–239

    Article  CAS  Google Scholar 

  • Dajani AS, Taubert KA, Wilson W, Bolger AF, Bayer A, Ferrieri P, Gewitz MH (1979) Prevention of bacterial endocarditis: recommendations by the American heart association. Clin Infect Dis 25:1448–1458

    Article  Google Scholar 

  • Dajani AS, Taubert KA, Wilson W (1997) Prevention of bacterial endocarditis: recommendations by the American Heart Association. JAMA 227(22):1794–1801

    Article  Google Scholar 

  • Durack DT (2005) Prophylaxis of infective endocarditis. In: Mandell GL, Bennett JE, Dolin R (eds) Mandell, Douglas and Bennett principles and practice of infectious diseases, 6th edn. Elsevier Churchill Livingstone, Philadelphia, pp 1044–1050

    Google Scholar 

  • Esposito M, Hirsch JM, Lekholm U, Thomsen P (1998) Biological factors contributing to failures of osseointegrated oral implants. (II) Etiopathogenesis. Eur J Oral Sci 106:721–764

    Article  CAS  Google Scholar 

  • Filoche S, Wong L, Sissons CH (2010) Oral biofilms: emerging concepts in microbial ecology. J Dent Res 89:8–18

    Article  CAS  Google Scholar 

  • Flemmig TF, Newman MG (1990) Antimicrobials in implant dentistry. In: Newman MG, Kornman K (eds) Antibiotics/antimicrobial use in dental practice. Quintessence Publishing Co, Chicago, pp 187–200

    Google Scholar 

  • Fujiwara M, Hayashi Y, Ohara N (2004) Inhibitory effect of water-soluble chitosan on growth of Streptococcus mutans. New Microbiol 27:83–86

    CAS  PubMed  Google Scholar 

  • Gauser MP, Bernard JP, Moreillon P, Francioli P (1983) Successful single dose amoxicillin prophylaxis against experimental streptococcal endocarditis: evidence for two mechanisms of protection. J Infect Dis 147:568–575

    Article  Google Scholar 

  • Genco RJ, Grossi SG, Ho A, Nishimura F, Murayama Y (2005) A proposed model linking inflammation to obesity, diabetes, and periodontal infections. J Periodontol 76:2075–2084

    Article  Google Scholar 

  • Groppo FC, Ramacciato JC, Simões RP, Flório FM, Sartoratto A (2002) Antimicrobial activity of garlic, tea tree oil, and chlorhexidine against oral microorganisms. Int Dent J 52:433–437

    Article  CAS  Google Scholar 

  • Haffajee AD, Socransky SS, Smith C, Duff GW (2000) Microbiological parameters associated with IL-1 gene polymorphisms in periodontitis patients. J Clin Periodontol 27(11):810–818

    Article  Google Scholar 

  • Hammer KA, Dry L, Johnson M, Michalak EM, Carson CF, Riley TV (2003) Susceptibility of oral bacteria to Melaleuca alternifolia (tea tree) oil in vitro. Oral Microbiol Immunol 18:389–392

    Article  CAS  Google Scholar 

  • Hattori M, Kusumoto IT, Namba T, Ishigami T, Hara Y (1990) Effect of tea polyphenols on glucan synthesis by glucosyltransferase from Streptococcus mutans. Chem Pharm Bull 38:717–720

    Article  CAS  Google Scholar 

  • Hayashi Y, Ohara N, Ganno T, Yamaguchi K, Ishizaki T, Nakamura T, Sato M (2007) Chewing chitosan-containing gum effectively inhibits the growth of cariogenic bacteria. Arch Oral Biol 52:290–294

    Article  CAS  Google Scholar 

  • Hirasawa M, Shouji N, Neta T, Fukushima K, Takada K (1999) Three kinds of antibacterial substances from Lentinus edodes (Berk) Sing (Shiitake, an edible mushroom). Int J Antimicrob Agents 11:151–157

    Article  CAS  Google Scholar 

  • Hu C-H, He J, Eckert R, Wu X-Y, Li L-N, Tian Y, Lux R, Shuffer JA, Gelman F, Mentes J, Spackman S, Bauer J, Anderson MH, Shi W‐Y (2011) Development and evaluation of a safe and effective sugar-free herbal lollipop that kills cavity-causing bacteria. Int J Oral Sci 3(1):13–20

    Article  Google Scholar 

  • Ikeno K, Ikeno T, Miyazawa C (1991) Effects of propolis on dental caries in rats. Caries Res 25:347–351

    Article  CAS  Google Scholar 

  • Joshipura KJ, Hung HC, Rimm EB, Willett WC, Ascherio A (2003) Periodontal disease, tooth loss, and incidence of ischemic stroke. Stroke 34:47–52

    Article  Google Scholar 

  • Karlowsky J, Ferguson J, Zhanel G (1993) A review of commonly prescribed oral antibiotics in general dentistry. J Can Dent Assoc 59(3):292–294

    CAS  PubMed  Google Scholar 

  • Koo H, Vacca Smith AM, Bowen WH, Rosalen PL, Cury JA, Park YK (2000) Effects of Apis mellifera propolis on the activities of streptococcal glucosyltransferases in solution and adsorbed onto saliva-coated hydroxyapatite. Caries Res 34:418–426

    Article  CAS  Google Scholar 

  • Koo H, Cury JA, Rosalen PL, Ambrosano GM, Ikegaki M, Park YK (2002a) Effect of a mouthrinse containing selected propolis on 3-day dental plaque accumulation and polysaccharide formation. Caries Res 36:445–448

    Article  CAS  Google Scholar 

  • Koo H, Pearson SK, Scott-Anne K, Abranches J, Cury JA, Rosalen PL, Park YK, Marquis RE, Bowen WH (2002b) Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. Oral Microbiol Immunol 17:337–343

    Article  CAS  Google Scholar 

  • Koo H, Hayacibara MF, Schobel BD, Cury JA, Rosalen PL, Park YK, Vacca-Smith AM, Bowen WH (2003) Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. J Antimicrob Chemother 52:782–789

    Article  CAS  Google Scholar 

  • Koo H, Schobel B, Scott-Anne K, Watson G, Bowen WH, Cury JA, Rosalen PL, Park YK (2005) Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries. J Dent Res 84:1016–1020

    Article  CAS  Google Scholar 

  • Lederberg J, Mccray AT (2001) ‘Ome sweet’ omics—a genealogical treasury of words. Scientist 15:8–10

    Google Scholar 

  • Lee JJ, Hahn LJ, Kao TP, Liu CH, Cheng SJ, Cheng SL, Chang HH, Jeng JH, Kok SH (2009) Post-tooth extraction sepsis without locoregional infection – a population-based study in Taiwan. Oral Dis 15:602–607

    Article  Google Scholar 

  • Linke HA, LeGeros RZ (2003) Black tea extract and dental caries formation in hamsters. Int J Food Sci Nutr 54:89–95

    Article  CAS  Google Scholar 

  • Lockhart PB, Loven B, Brennan MT, Baddour LM, Levinson M (2007) The evidence base for the efficiency of anti-biotic prophylaxis in dental practice. J Am Dent Assoc 138(4):458–474

    Article  Google Scholar 

  • Marsh PD, Martin MV, Lewis MAO, Williams DW (2009) Oral microbiology, 5th edn. Churchill Livingstone Elsevier, p 153

    Google Scholar 

  • Montefusco V, Gay F, Spina F (2008) Antibiotic prophylaxis before dental procedures may reduce the incidence of osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates. Leuk Lymphoma 49(11):2156–2162

    Article  CAS  Google Scholar 

  • Newman MG, van Winkelhoff AJ (2001) Antibiotic and antimicrobial use in dental practice, 2nd edn. Quintessence Publishing Co, Hanover Park, p 120

    Google Scholar 

  • NICE Guidelines, Thornhill MH, Dayer M, Lockhart PB, McGurk M, Shanson D, Prendergast B, Chambers JB (2016) A change in the NICE guidelines on antibiotic prophylaxis. Br Dent J 221:112–114

    Article  Google Scholar 

  • Offenbacher S, Jared HL, O'Reilly PG, Wells SR, Salvi GE, Lawrence HP, Socransky SS, Beck JD (1998) Potential pathogenic mechanisms of periodontitis associated pregnancy complications. Ann Periodontol 3:233–250

    Article  CAS  Google Scholar 

  • Pandit S, Kim H-J, Kim J-E, Jeon J-G (2011) Separation of an effective fraction from turmeric against Streptococcus mutans biofilms by the comparison of curcuminoid content and anti-acidogenic activity. Food Chem 126(4):1565–1570

    Article  CAS  Google Scholar 

  • Parahitiyawa NB, Jin LJ, Leung WK, Yam WC, Samaranayake LP (2009) Microbiology of odontogenic bacteremia: beyond endocarditis. Clin Microbiol Rev 22:46–64

    Article  CAS  Google Scholar 

  • Rasooli I, Shayegh S, Taghizadeh M, Astaneh SD (2008) Phytotherapeutic prevention of dental biofilm formation. Phytother Res 22:1162–1167

    Article  Google Scholar 

  • Ribeiro AA, Azcarate-Peril MA, Cadenas MB, Butz N, Paster BJ, Chen T, Bair E, Arnold RR (2017) The oral bacterial microbiome of occlusal surfaces in children and its association with diet and caries. PloS one 12(7):e0180621

    Article  Google Scholar 

  • Rogers SN, Hung J, Barber AJ, Lowe D (2009) A survey of consultant members of the British Association of Oral and Maxillofacial Surgeons regarding bisphosphonate-induced osteonecrosis of the jaws. Br J Oral Maxillofac Surg 47(8):598–601

    Article  CAS  Google Scholar 

  • Ruby J, Barbeau J (2002) The buccale puzzle: the symbiotic nature of endogenous infections of the oral cavity. Can J Infect Dis 13:34–41

    Article  Google Scholar 

  • Sanz M, van Winkelhoff AJ, Herrera D, Dellemijn-Kippuw N, Simón R, Winkel E (2000) Differences in the composition of the subgingival microbiota of two periodontitis populations of different geographical origin. A comparison between Spain and the Netherlands. Eur J Oral Sci 108(5):383–392

    Article  CAS  Google Scholar 

  • Sasaki H, Matsumoto M, Tanaka T, Maeda M, Nakai M, Hamada S, Ooshima T (2004) Antibacterial activity of polyphenol components in oolong tea extract against Streptococcus mutans. Caries Res 38:2–8

    Article  CAS  Google Scholar 

  • Sato S, Yoshinuma N, Ito K, Tokumoto T, Takiguchi T, Suzuki Y, Murai S (1998) The inhibitory effect of funoran and eucalyptus extract-containing chewing gum on plaque formation. J Oral Sci 40:115–117

    Article  CAS  Google Scholar 

  • Seppänen L, Lauhio A, Lindqvist C, Suuronen R, Rautemaa R (2008) Analysis of systemic and local odontogenic infection complications requiring hospital care. J Infect 57:116–122

    Article  Google Scholar 

  • Seymour RA (2017) Antibiotics in dentistry – an update. Newcastle University, Newcastle upon Tyne

    Google Scholar 

  • Seymour GJ, Ford PJ, Cullinan MP, Leishman S, Yamazaki K (2007) Relationship between periodontal infections and systemic disease. Clin Microbiol Infect 13(Suppl. 4):3–10

    Article  CAS  Google Scholar 

  • Shinada K, Tagashira M, Watanabe H, Sopapornamorn P, Kanayama A, Kanda T, Ikeda M, Kawaguchi Y (2007) Hop bract polyphenols reduced three-day dental plaque regrowth. J Dent Res 86:848–851

    Article  CAS  Google Scholar 

  • Shouji N, Takada K, Fukushima K, Hirasawa M (2000) Anticaries effect of a component from shiitake (an edible mushroom). Caries Res 34:94–98

    Article  CAS  Google Scholar 

  • Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL (1998) Microbial complexes in subgingival plaque. J Clin Periodontol 25(2):134–144

    Article  CAS  Google Scholar 

  • Stookey GK, McDonald Jr JL (1974) Further studies of the cariostatic properties of tin (II) and oat hulls in the rat. J Dent Res 53:1398–1403

    Article  CAS  Google Scholar 

  • Tagashira M, Uchiyama K, Yoshimura T, Shirota M, Uemitsu N (1997) Inhibition by hop bract polyphenols of cellular adherence and water-insoluble glucan synthesis of mutans streptococci. Biosci Biotechnol Biochem 61:332–335

    Article  CAS  Google Scholar 

  • Takarada K, Kimizuka R, Takahashi N, Honma K, Okuda K, Kato T (2004) A comparison of the antibacterial efficacies of essential oils against oral pathogens. Oral Microbiol Immunol 19:61–64

    Article  CAS  Google Scholar 

  • Tarsi R, Muzzarelli RA, Guzmán CA, Pruzzo C (1997) Inhibition of Streptococcus mutans adsorption to hydroxyapatite by low-molecular-weight chitosans. J Dent Res 76:665–672

    Article  CAS  Google Scholar 

  • Tate AR, Norris CK, Minniti CP (2006) Antibiotic prophylaxis for children with sickle cell disease: a survey of pediatric dentistry residency program directors and pediatric hematologists. Pediatr Dent 28(3):332–335

    PubMed  Google Scholar 

  • Tichy J, Novak J (1998) Extraction, assay, and analysis of antimicrobials from plants with activity against dental pathogens (Streptococcus sp.) J Altern Complement Med 4(1):39–45

    Article  CAS  Google Scholar 

  • Touyz LZ, Amsel R (2001) Anticariogenic effects of black tea (Camellia sinensis) in caries-prone rats. Quintessence Int 32:647–650

    CAS  PubMed  Google Scholar 

  • Vogel JJ, Thompson DJ, Phillips PH (1962) Studies on the anticariogenic activity of oat hulls. J Dent Res 41:707–712

    Article  CAS  Google Scholar 

  • Yanti, Rukayadi Y, Kim KH, Hwang JK (2008) In vitro anti-biofilm activity of macelignan isolated from Myristica fragrans Houtt. Against oral primary colonizer bacteria. Phytother Res PTR 22(3):308–312

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India

    Jerusha Santa Packyanathan

  2. Department of Biotechnology, Hindustan college of Arts & Sciences, Chennai, Tamil Nadu, India

    C. Elizabeth Rani Juneius & M. Vinoth

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  1. Jerusha Santa Packyanathan
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  2. C. Elizabeth Rani Juneius
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  3. M. Vinoth
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Correspondence to C. Elizabeth Rani Juneius .

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Editors and Affiliations

  1. Dongguk University, Goyang-si, Korea (Republic of)

    Jayanta Kumar Patra

  2. Dongguk University, Goyang-si, Korea (Republic of)

    Gitishree Das

  3. Dongguk University, Goyang-si, Korea (Republic of)

    Han-Seung Shin

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Packyanathan, J.S., Rani Juneius, C.E., Vinoth, M. (2018). Recent Antibiotics Used in Dental Disease Management. In: Patra, J., Das, G., Shin, HS. (eds) Microbial Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-10-7140-9_24

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