Early Postoperative Intraperitoneal Chemotherapy: Current Role and Future Perspectives

  • T. Douchy
  • L. Lemoine
  • K. Van der Speeten


The introduction of cytoreductive surgery and hyperthermic intraperitoneal perioperative chemotherapy has greatly improved the prognosis of patients with peritoneal carcinomatosis. In spite of these improvements, the majority of patients still die of intra-abdominal dissemination. Several strategies to consolidate and improve these results are being explored. The aim of this manuscript is to evaluate early postoperative intraperitoneal chemotherapy as a possible leverage point to further improve multimodal therapy of peritoneal carcinomatosis.


EPIC Clinical evidence for EPIC EPIC drug regimens HIPEC 5-FU Taxanes Peritoneal carcinomatosis 



Area under the curve


Bidirectional intraoperative chemotherapy


Completeness of cytoreduction


Colorectal carcinoma


Cytoreductive surgery


Diffuse malignant peritoneal mesothelioma


Early postoperative intraperitoneal chemotherapy




Hyperthermic intraperitoneal perioperative chemotherapy


Intraperitoneal chemotherapy




Mitomycin C


Not available


Neoadjuvant intraperitoneal and systemic chemotherapy


Overall survival


Peritoneal carcinomatosis index


Progression-free survival


Peritoneal metastases


Sequenced intraperitoneal chemotherapy



Lemoine L. is supported by the Agency for Innovation by Science and Technology (IWT) in Brussels, Belgium. Lemoine L. is a researcher for the Limburg Clinical Research Program (LCRP) UHasselt-ZOL-Jessa, supported by the foundation Limburg Sterk Merk (LSM), Hasselt University, Ziekenhuis Oost-Limburg and Jessa Hospital, Belgium.


No conflicts of interest.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Surgical OncologyZiekenhuis Oost-LimburgGenkBelgium
  2. 2.Department of Biochemistry, Faculty of MedicineUniversity HasseltDiepenbeekBelgium
  3. 3.Washington Cancer Institute, Washington Hospital CenterWashington, DCUSA

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