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Small Angle Scattering for Pharmaceutical Applications: From Drugs to Drug Delivery Systems

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Biological Small Angle Scattering: Techniques, Strategies and Tips

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1009))

Abstract

The sub-nanometer scale provided by small angle neutron and X-ray scattering is of special importance to pharmaceutical and biomedical investigators. As drug delivery devices become more functionalized and continue decreasing in size, the ability to elucidate details on size scales smaller than those available from optical techniques becomes extremely pertinent. Information gathered from small angle scattering therefore aids the endeavor of optimizing pharmaceutical efficacy at its most fundamental level. This chapter will provide some relevant examples of drug carrier technology and how small angle scattering (SAS) can be used to solve their mysteries. An emphasis on common first-step data treatments is provided which should help clarify the contents of scattering data to new researchers. Specific examples of pharmaceutically relevant research on novel systems and the role SAS plays in these studies will be discussed. This chapter provides an overview of the current applications of SAS in drug research and some practical considerations for selecting scattering techniques.

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Acknowledgement

This work was supported by NSF Career Award 1350370.

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Authors and Affiliations

  1. Department of Chemistry, University of Alabama at Birmingham, 901 14th Street South, CHEM 272, Birmingham, AL, 35294, USA

    Aaron Alford, Veronika Kozlovskaya & Eugenia Kharlampieva

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  1. Aaron Alford
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  2. Veronika Kozlovskaya
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  3. Eugenia Kharlampieva
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Corresponding author

Correspondence to Eugenia Kharlampieva .

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Editors and Affiliations

  1. G N Ramachandran Protein Center, CSIR Institute of Microbial Technology, Chandigarh, India

    Barnali Chaudhuri

  2. Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

    Inés G. Muñoz

  3. Center for Structural Molecular Biology and Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    Shuo Qian

  4. Center for Structural Molecular Biology and Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    Volker S. Urban

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Alford, A., Kozlovskaya, V., Kharlampieva, E. (2017). Small Angle Scattering for Pharmaceutical Applications: From Drugs to Drug Delivery Systems. In: Chaudhuri, B., Muñoz, I., Qian, S., Urban, V. (eds) Biological Small Angle Scattering: Techniques, Strategies and Tips. Advances in Experimental Medicine and Biology, vol 1009. Springer, Singapore. https://doi.org/10.1007/978-981-10-6038-0_15

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