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Proteases in Wound Healing and Immunity

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Proteases in Human Diseases

Abstract

Proteases play a pivotal role in wound management. They are present in acute and chronic wound in different proportions. Balance between protease and their inhibitors are crucial for healing of wound because irregularity can lead to excessive extracellular matrix (ECM) degradation and deposition leading to impaired healing. Recent advancements in wound care established several means to control the level of proteases, such as MMP modulators including protease-modulating dressing, signaling molecules, peptides, and microRNA. Besides wound healing, proteases also play a significant role in immunity. They activate immune cells by proteolysis. Function of proteases in the areas of wound healing and immunity can be targeted as an alternative therapeutic approach for treatment.

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Acknowledgements

NS was supported by DST-INSPIRE fellowship, New Delhi.

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  1. Division of Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Jadavpur, Kolkata, 700032, India

    Namrata Singh & Debasish Bhattacharyya

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  1. Namrata Singh
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  2. Debasish Bhattacharyya
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Correspondence to Debasish Bhattacharyya .

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  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Tapati Chakraborti

  3. Department of Physiology, Faculty of Medicine, St. Boniface General Hospital, Institute of Cardiovascular Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Singh, N., Bhattacharyya, D. (2017). Proteases in Wound Healing and Immunity. In: Chakraborti, S., Chakraborti, T., Dhalla, N. (eds) Proteases in Human Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-10-3162-5_8

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