Overview
Provides a comprehensive investigation into the regulation of proteases and their pathological consequences in health and disease
Explores the specific inhibitors and molecular probes for proteases to improve therapy for various diseases
Contains informative resource to improve diverse protease targeted therapeutic approaches of life-threatening diseases
Includes supplementary material: sn.pub/extras
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Table of contents (24 chapters)
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Front Matter
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Involvement of Proteases in Various Diseases
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Front Matter
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Keywords
About this book
This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions.
Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues.
Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
Editors and Affiliations
About the editors
Dr. Naranjan S Dhalla is a Distinguished Professor at the University of Manitoba, Winnipeg, Canada. His expertise includes the subcellular and molecular basis of heart function in health and disease. He has been engaged in multidisciplinary research and education for promoting the scientific basis of cardiology, as well as training of professional manpower for combating heart disease for over 50 years.
Dr. Tapati Chakraborti is a Professor of Biochemistry at the University of Kalyani, West Bengal, India. Her research covers role of proteases in the pathophysiology of Leishmaniasis. She is also doing research on the role of proteases in regulating pulmonary vascular tone. She has been engaged in teaching and research in biochemistry for the past 30 years.
Bibliographic Information
Book Title: Proteases in Human Diseases
Editors: Sajal Chakraborti, Tapati Chakraborti, Naranjan S. Dhalla
DOI: https://doi.org/10.1007/978-981-10-3162-5
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2017
Hardcover ISBN: 978-981-10-3161-8Published: 26 July 2017
Softcover ISBN: 978-981-10-9806-2Published: 12 May 2018
eBook ISBN: 978-981-10-3162-5Published: 13 July 2017
Edition Number: 1
Number of Pages: XVII, 513
Number of Illustrations: 11 b/w illustrations, 52 illustrations in colour
Topics: Human Physiology, Molecular Medicine, Pharmaceutical Sciences/Technology, Cancer Research
Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma