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Kinesin-8 Members and Their Potential as Biomarker or Therapeutic Target

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Kinesins and Cancer

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Abstract

The kinesin-8 family is unique among kinesins in that its members have the ability both to walk along microtubules and to specifically influence the dynamics of microtubule plus-ends. This capacity is used to regulate microtubule length and dynamic behavior. Kif18A is the most studied member of the human kinesin-8 family. Its mRNA – and in some cases the protein – has been found elevated in several cancers and this correlates with poor prognosis. However, there is little evidence to date that these high levels actively promote tumorigenesis. Because Kif18A abundance is higher in mitotic cells, the increased abundance may reflect a higher percentage of proliferative cells. Reduction of Kinesin-8 delays cells in mitosis and perturbs microtubule dynamics. Inhibitors of Kinesin-8 may therefore influence the proliferative capacity or may impair the migratory potential of cancer cells. These ideas remain to be tested.

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Authors and Affiliations

  1. Department of Biology and Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany

    Thomas U. Mayer

  2. Department of Biological Sciences and Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA

    Silke Hauf

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  1. Thomas U. Mayer
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  2. Silke Hauf
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Correspondence to Thomas U. Mayer .

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  1. Chair, Department of Pharmaceutical and Biological Chemistry School of Pharmacy, University College London, London, United Kingdom

    Frank Kozielski, FSB

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Mayer, T.U., Hauf, S. (2015). Kinesin-8 Members and Their Potential as Biomarker or Therapeutic Target. In: Kozielski, FSB, F. (eds) Kinesins and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9732-0_11

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