Kinesins and Cancer

  • Frank Kozielski, FSB

Table of contents

  1. Front Matter
    Pages i-x
  2. Kristen J. Verhey, Jared C. Cochran, Claire E. Walczak
    Pages 1-26
  3. James A. D. Good, Giacomo Berretta, Nahoum G. Anthony, Simon P. Mackay
    Pages 27-52
  4. Robert A. Cross
    Pages 53-62
  5. Steven S. Rosenfeld
    Pages 63-76
  6. Roy G. H. P. van Heesbeen, René H. Medema
    Pages 77-86
  7. Julien Espeut, Ariane Abrieu
    Pages 87-99
  8. Vaishali Pannu, Padmashree C. G. Rida, Ritu Aneja
    Pages 101-116
  9. Manjari Mazumdar, Tom Misteli
    Pages 135-147
  10. Brigitte L. Thériault, Timothy W. Corson
    Pages 149-170
  11. Ryan D. Baron, Francis A. Barr
    Pages 193-222
  12. Robert L. Margolis, Mythili Yenjerla
    Pages 223-249
  13. Back Matter
    Pages 269-271

About this book

Introduction

This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as potential targets for drug development in cancer chemotherapy. The work begins by highlighting the importance of kinesins, summarising current knowledge and how they are shown to be crucial for mitosis. Chapters go on to explore how this family of proteins are emerging as a novel target for chemotherapeutic intervention and drug development.

Readers will learn how kinesins travel along microtubules to fulfill their many roles in intracellular transport or cell division. Several compounds that inhibit two mitotic kinesins (called Eg5 and CENP-E) have entered Phase I and II clinical trials and are explored in these chapters. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the repertoire of kinesin-based drug targets may expand in the future.

The book is suitable as a reference standard for the field of kinesins and cancer. It will interest those in academia and pharmaceutical companies, and anyone with an interest in the medical relevance of these proteins, which cutting edge methodologies are now enabling us to understand in astonishing detail.

Keywords

Cancer chemotherapy Human mitotic kinesins Mitotic spindle as a validated target Molecular motors Target validation/drug development

Editors and affiliations

  • Frank Kozielski, FSB
    • 1
  1. 1.Chair, Department of Pharmaceutical and Biological Chemistry School of Pharmacy, University College LondonLondonUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-017-9732-0
  • Copyright Information Springer Science+Business Media Dordrecht 2015
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-017-9731-3
  • Online ISBN 978-94-017-9732-0
  • About this book
Industry Sectors
Biotechnology
Consumer Packaged Goods
Pharma