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The Kinesin Superfamily

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Kinesins and Cancer

Abstract

Kinesins are enzymes that use the energy of ATP hydrolysis to generate force and/or motility along microtubule polymers. A large number of kinesin enzymes are involved in mitosis with important roles in spindle assembly, chromosome congression, chromosome segregation, and cytokinesis. In this chapter, we begin with a description of the kinesin motor domain and the general principles of chemomechanical coupling. We then discuss general principles of kinesin organization and regulation. Finally, we provide a brief description of the kinesins that are known to function in mitosis, which will be the focus of the later chapters of this book.

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  1. Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA

    Kristen J. Verhey

  2. Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, 47405, USA

    Jared C. Cochran

  3. Medical Sciences, Indiana University, Bloomington, IN, 47405, USA

    Claire E. Walczak

Authors
  1. Kristen J. Verhey
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  2. Jared C. Cochran
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  3. Claire E. Walczak
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Corresponding author

Correspondence to Kristen J. Verhey .

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Editors and Affiliations

  1. Chair, Department of Pharmaceutical and Biological Chemistry School of Pharmacy, University College London, London, United Kingdom

    Frank Kozielski, FSB

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© 2015 Springer Science+Business Media Dordrecht

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Verhey, K.J., Cochran, J.C., Walczak, C.E. (2015). The Kinesin Superfamily. In: Kozielski, FSB, F. (eds) Kinesins and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9732-0_1

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