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Structural Bases of Receptor-JAK-STAT Interactions

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Signal Transducers and Activators of Transcription (STATs)

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Abstract

The recognition of hematopoietic cytokines and interferons by their receptors and the assembly of all receptor chains is followed by the activation of Janus kinases (JAKs), phosphorylation of receptor tyrosine motifs and the subsequent recruitment of signal transducers and activators of transcription (STATs) as crucial events for the initiation of signalling. These cytokines use different combinations of JAKs (JAK1, JAK2, JAK3, TYK2) and STATs (STAT1 to STAT6) to exert their function. This chapter reviews the structural bases of receptor-JAK-STAT interactions taking the interleukin (IL)-6 type cytokine system as a paradigm. The IL-6-type cytokines IL-6, IL-11, LIF, OSM, CNTF, CT-1 and CLC constitute an important family of mediators which act via the signal transducers gp130, LIF receptor and OSM receptor.

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Author information

Authors and Affiliations

  1. Institut für Biochemie, Universitätsklinikum der RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany

    Peter C. Heinrich, Iris Behrmann, Serge Haan, Heike M. Hermanns, Gerhard Müller-Newen & Fred Schaper

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  1. Peter C. Heinrich
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  2. Iris Behrmann
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  3. Serge Haan
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  4. Heike M. Hermanns
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  5. Gerhard Müller-Newen
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  6. Fred Schaper
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Editors and Affiliations

  1. New York University School of Medicine, USA

    Pravin B. Sehgal  & David E. Levy  & 

  2. Osaka University, Japan

    Toshio Hirano

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Heinrich, P.C., Behrmann, I., Haan, S., Hermanns, H.M., Müller-Newen, G., Schaper, F. (2003). Structural Bases of Receptor-JAK-STAT Interactions. In: Sehgal, P.B., Levy, D.E., Hirano, T. (eds) Signal Transducers and Activators of Transcription (STATs). Springer, Dordrecht. https://doi.org/10.1007/978-94-017-3000-6_4

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  • DOI: https://doi.org/10.1007/978-94-017-3000-6_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6421-9

  • Online ISBN: 978-94-017-3000-6

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