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STAT Transcriptional Activation Mechanisms

Communication with the basal transcriptional machinery

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Signal Transducers and Activators of Transcription (STATs)

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Abstract

STAT transcription factors act as switches that convert extracellular signals into cellular action. While the structures underlying this switch, including signal-dependent phosphorylation, dimerization, nuclear translocation, and DNA binding are highly conserved among STAT family members, the biochemistry of effector actions is remarkably diverse. The business end of the molecule contains a transactivation domain that functions by interactions with other transcription factors, with coactivators, and with subunits of the basal transcriptional machinery. Evolutionary pressures have driven the development of STAT transactivation domains such that each family member solves its effector challenges in a unique manner.

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Author information

Authors and Affiliations

  1. Molecular Oncology and Immunology Program, Departments of Pathology and Microbiology and the NYU Cancer Institute, New York University School of Medicine, 550 First Ave., New York, NY, 10016, USA

    David E. Levy

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  1. David E. Levy
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Editors and Affiliations

  1. New York University School of Medicine, USA

    Pravin B. Sehgal  & David E. Levy  & 

  2. Osaka University, Japan

    Toshio Hirano

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Levy, D.E. (2003). STAT Transcriptional Activation Mechanisms. In: Sehgal, P.B., Levy, D.E., Hirano, T. (eds) Signal Transducers and Activators of Transcription (STATs). Springer, Dordrecht. https://doi.org/10.1007/978-94-017-3000-6_22

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  • DOI: https://doi.org/10.1007/978-94-017-3000-6_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6421-9

  • Online ISBN: 978-94-017-3000-6

  • eBook Packages: Springer Book Archive

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