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X-Ray Crystal Structure of STAT Proteins and Structure-Activity Relationships

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Signal Transducers and Activators of Transcription (STATs)

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Abstract

STAT proteins have intrigued molecular and structural biologists for many years. The seemingly simple mechanism of activation through well known signalling components and the vast biological versatility of their functions had to be reconciled. Much hope rested on information gained from the structural features of the STAT molecules. The same is true for insights into the binding partners of STATs, molecules which might distinguish STAT functions in different cell types and as a result of different signalling origins. The goal of these studies is the merger of the combinatorial action of STAT molecules with other signal components responsible for distinct biological outcomes and the structural basis for such protein-protein interactions.

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Author information

Authors and Affiliations

  1. European Molecular Biology Laboratory, Grenoble Outstation, BP 181, 38042, Grenoble Cedex 9, France

    Christoph W. Müller & Montserrat Soler-Lopez

  2. Georg Speyer Haus, Institute for Biomedical Research, Paul Ehrlich Street 42-44, D-60596, Frankfurt, Germany

    Christina Gewinner & Bernd Groner

Authors
  1. Christoph W. Müller
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  2. Montserrat Soler-Lopez
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  3. Christina Gewinner
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  4. Bernd Groner
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Editor information

Editors and Affiliations

  1. New York University School of Medicine, USA

    Pravin B. Sehgal  & David E. Levy  & 

  2. Osaka University, Japan

    Toshio Hirano

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© 2003 Springer Science+Business Media Dordrecht

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Müller, C.W., Soler-Lopez, M., Gewinner, C., Groner, B. (2003). X-Ray Crystal Structure of STAT Proteins and Structure-Activity Relationships. In: Sehgal, P.B., Levy, D.E., Hirano, T. (eds) Signal Transducers and Activators of Transcription (STATs). Springer, Dordrecht. https://doi.org/10.1007/978-94-017-3000-6_21

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  • DOI: https://doi.org/10.1007/978-94-017-3000-6_21

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6421-9

  • Online ISBN: 978-94-017-3000-6

  • eBook Packages: Springer Book Archive

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