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Raft-STAT Signaling and Transcytoplasmic Trafficking

  • Chapter
Signal Transducers and Activators of Transcription (STATs)

Abstract

In the last few years this and other laboratories have obtained data suggesting that cytokine-STAT signaling in many different cell-types is likely to be a chaperoned pathway initiated at the level of specialized plasma membrane microdomains called “rafts” (the “raft-STAT signaling hypothesis”)(1, 2). These findings are of broad significance in that all cytokines and growth factors initiate signaling in target cells by interacting with respective cell-surface receptors. The new data suggest that raft microdomains represent the units of function at the cell-surface through which ligand-stimulated STAT signaling is initiated. In this review, we shall briefly summarize recent data relevant to an understanding of the subcellular anatomy of cytokine- and growth factor- activated STAT signaling at the level of the plasma membrane and the role of integral raft proteins such as caveolin-1 (cav-1) in modulating this pathway.

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Author information

Authors and Affiliations

  1. Dept. of Cell Biology & Anatomy, and of Medicine, New York Medical College, Valhalla, NY, 10595, USA

    Pravin B. Sehgal & Mehul Shah

Authors
  1. Pravin B. Sehgal
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  2. Mehul Shah
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Editors and Affiliations

  1. New York University School of Medicine, USA

    Pravin B. Sehgal  & David E. Levy  & 

  2. Osaka University, Japan

    Toshio Hirano

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Sehgal, P.B., Shah, M. (2003). Raft-STAT Signaling and Transcytoplasmic Trafficking. In: Sehgal, P.B., Levy, D.E., Hirano, T. (eds) Signal Transducers and Activators of Transcription (STATs). Springer, Dordrecht. https://doi.org/10.1007/978-94-017-3000-6_17

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  • DOI: https://doi.org/10.1007/978-94-017-3000-6_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6421-9

  • Online ISBN: 978-94-017-3000-6

  • eBook Packages: Springer Book Archive

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