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Use of Plant Virus-Based Expression Systems for the Production of HIV Vaccines

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Molecular Farming of Plants and Animals for Human and Veterinary Medicine

Abstract

The number of patients carrying acquired immune deficiency syndrome (AIDS) keeps increasing as new infections with human immunodeficiency virus (HIV) continue to occur. Although anti-retroviral drug therapies are capable of reducing viral load of infected patients, it is clear that the effective and ultimate solution to control AIDS is vaccination against HIV infection. Recent development of HIV vaccines has shown great promise and different stages of HIV vaccine clinical trials in humans are currently being conducted worldwide. However, vaccines produced using traditional production systems are costly and future products may be unaffordable in developing counties, where most HIV infections occur. Several plant-based systems have been developed and are being optimized for cost effective production of vaccines. RNA plant viruses have attracted great interest because of their utility in over expressing vaccine antigens. In addition, plant virus-derived products have been shown to be effective in inducing immunoresponses when administered to animals. Results from these studies support the further development of plant virus-based expression systems for the production of cost effective HIV vaccines. This chapter focuses on the recent development of RNA plant virus-based expression systems and the immunogenicity and potential clinical applications of plant virus-derived HIV vaccines.

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Authors and Affiliations

  1. Genesis Research and Development Corporation Ltd., PO Box 50, Auckland, New Zealand

    G. G. Zhang

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  1. G. G. Zhang
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Editors and Affiliations

  1. Department of Plant Agriculture, University of Guelph, Geulph, Ontario, Canada

    L. Erickson

  2. Syngenta Biotechnology Inc., Research Triangle Park, North Carolina, USA

    W.-J. Yu

  3. Research Branch, Agriculture and Agri-Food Canada, London, Ontario, Canada

    J. Brandle  & R. Rymerson  & 

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Zhang, G.G. (2002). Use of Plant Virus-Based Expression Systems for the Production of HIV Vaccines. In: Erickson, L., Yu, WJ., Brandle, J., Rymerson, R. (eds) Molecular Farming of Plants and Animals for Human and Veterinary Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2317-6_7

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  • DOI: https://doi.org/10.1007/978-94-017-2317-6_7

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