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An Overview of Biodegradable Polymers and Biodegradation of Polymers

  • Chapter
Degradable Polymers

Abstract

It is now widely recognized that, along with the importance of synthetic polymers possessing long-term stability, there is also a need for polymers that break down in a controlled manner. Biodegradable macromolecules can be tailored specifically for controlled degradation under the inherent environmental stress in biological systems either unaided or by enzyme-assisted mechanisms. Medical applications of these materials have led to significant developments, such as the controlled release of drugs, fertilizers and pesticides, absorbable surgical implants, skin grafts and bone plates. Many studies of the mechanisms of biodegradation of synthetic polymers were motivated by this and will be initially discussed. Recent interest in polymer waste management of packaging materials has and incentive to the research and will be discussed in a later section.

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References

  1. Szivek, J. A., Weatherly, G. C., Pilliar, R. M. and Cameron, H. U. (1981) J. Biomed. Res., 15, 853.

    Google Scholar 

  2. Brown, S. A. and Mayor, M. B. (1978) J. Biomed. Res., 12, 67.

    Article  CAS  Google Scholar 

  3. Woo, S. L.-Y., Akeson, W. H., Levenetz, B. et al. (1974) J. Biomed. Mater. Res., 8, 321

    Google Scholar 

  4. Gourlay, S. J. Rice, R. M., Hegyeli, A. F. et al. (1978) J. Biomed Mater. Res.,12 219.

    Google Scholar 

  5. Rice, R. M., Hegyeli, A. F., Gourlay, S. J. et al. (1978) J. Biomed. Mat. Res., 12, 43.

    Google Scholar 

  6. Huang, S. J., Bitritto, M., Leong, K. W. et al. (1978) in Adv. Chem. Ser. No. 169, Stabilization and Degradation of Polymers (eds D. L. Allara and W. L. Hawkins,) American Chemical Society, p. 205.

    Google Scholar 

  7. Huang, S. J. and Roby, M. S. (1986) J. Bioact. Compat. Polym., 1, 61.

    Article  CAS  Google Scholar 

  8. Gilding, D. K. (1982) in Biocompatibility of Clinical Implant Materials,Vol II (ed. D. F. Williams), CRC Press, Boca Raton, FL.

    Google Scholar 

  9. Heller, J. (1983) in Initiation of Polymerization (ed. F. E. Bailey ), ACS Symp. Ser. No. 212, p. 373.

    Book  Google Scholar 

  10. Huang, S. J. (1985) in Encyclopedia of Polymer Science and Engineering, Vol. 2, 2nd edn, (eds Mark, Bikales, Overberger and Menges ), pp. 220–244.

    Google Scholar 

  11. Williams, D. F. (1982) J. Mater. Sci., 17, 1233.

    Google Scholar 

  12. Huang, S. J., Bansleben, D. A. and Knox, J. R. (1979) J. Appl. Polym. Sci., 23, 429.

    Article  CAS  Google Scholar 

  13. Huang, S. J. Bell, J. P., Knox, J. R.et al. (1976) inProc. 3rd Int. Biodeg. Symp.(eds J. M. Sharpley and A. M. Kaplan), Applied Science Publishers, London, p. 731.

    Google Scholar 

  14. Bitritto, M. M., Bell, J. R, Brenide, G. M. et al. (1979) J. Appl. Polym. Sci., Appl. Polym. Symp., 35, 405.

    Google Scholar 

  15. Bell, J. P., Huang, S. J. and Knox, J. R. (1974) TR 75–48-CEMEL, US Army, Natick Laboratory, Natick, MA.

    Google Scholar 

  16. Williams, D. J. (1981) J. Biomed. Mater. Res., 14, 329.

    Article  Google Scholar 

  17. Chu, C. C. (1981) J. Biomed. Mater. Res., 15, 19.

    Article  CAS  Google Scholar 

  18. Chu, C. C. and Louis, M. (1985) J. Appl. Polym. Sci., 30, 3133.

    Article  CAS  Google Scholar 

  19. Huffman, K. R. and Casey, D. J. (1985) J. Polym. Sci., Polym. Chem. Ed., 23, 1939.

    Article  CAS  Google Scholar 

  20. Chu, C.C. (1985) Polym., 26, 591.

    Article  CAS  Google Scholar 

  21. Fredericks, R. J., Melveger, A. J. and Dolegiewitz, L. J. (1984) J. Polym. Sci., Polym. Phys. Ed., 22, 57.

    Google Scholar 

  22. Kricheldorf, H. R. and Serra, A. (1985) Polym. Bull., 14, 497.

    Google Scholar 

  23. Dunsing, R. and Kricheldorf, H. R. (1985) Polym. Bull., 14, 491.

    Article  CAS  Google Scholar 

  24. Tune, D. C. (1986) Polym. Prepr., 27 (1), 431.

    Google Scholar 

  25. Jarrett, P., Cook, W. J., Bell, J. P. et al. (1981) Polym. Prepr., 22 (2), 351.

    CAS  Google Scholar 

  26. Cook, W. J., Cameron, J. A., Bell, J. P. and Huang, S J. (1981) J. Polym. Sci., Polym. Lett. Ed., 19, 159.

    Google Scholar 

  27. Jarrett, R., Huang, S. J., Bell, J. P. et al. (1982) Org. Coat. Plast. Chem. Proc., 47, 45.

    Google Scholar 

  28. Jarrett, R., Benedict, C., Bell, J. P. et al. (1983) Polym. Prepr., 24(1), 32.

    Google Scholar 

  29. Jarrett, R., Benedict, C. V., Bell, J. P. et al. (1984) in Polymers as Biomaterials, (eds S. W. Shalaby, A. S. Hoffman, B. D. Ratner, and T. A. Horbett), Plenum Press, New York, p. 181.

    Google Scholar 

  30. Pitt, C. G., Chaslow, F. I., Hibionada, Y. M. et al. (1981) J. Appl. Polym. Sci., 26, 3779.

    Google Scholar 

  31. Christel, P., Chabot, F., Leray, J. L. et al. (1982) Biomat., 1980, 271.

    Google Scholar 

  32. Vert, M., Chabot, F., Leray, J. and Christel, P. (1981) Makromol. Chem. Suppl., 5, 30.

    Google Scholar 

  33. Kulkarni, R. K., Moore, E. G., Hegycli, A. F. and Leonard, F. (1971) J. Biomed Mater. Res., 5, 169.

    Google Scholar 

  34. Miller, R. A., Brady, J. M. and Cutright, D. E. (1977) J. Biomed Mater. Res., 11, 711.

    Google Scholar 

  35. Bilding, D. K. and Reed, A. M. (1979) Polym., 20, 1459.

    Google Scholar 

  36. Reed, A. M. and Gilding, D. K. (1981) Polym., 22, 494.

    Google Scholar 

  37. Carter, B. K. and Wilkes, G. L. (1984) in Polymers as Biomaterials, (eds S. W. Shalaby, A. S. Hoffman, B. D. Ratner and T. A. Horbett) Plenum Press, New York, p. 67.

    Google Scholar 

  38. Mohajer, Y., Wilkes, G. L. and Orler, B. (1984) Polym. Sci. Eng., 24 (5), 319.

    Article  CAS  Google Scholar 

  39. Pitt, C. G., Jeffcoat, A. R., Zweidinger, R. A. and Schindler, A. (1979) J. Biomed Mater. Res., 13, 497.

    Google Scholar 

  40. Feng, X. D., Song, C. X. and Chen, W. Y. (1983) J. Polym. Sci., Polym. Lett. Ed., 21, 593.

    Google Scholar 

  41. Song, C. X. and Feng, X. D. (1984) Macromol.,17, 2764.

    Google Scholar 

  42. Shalaby, S. W. and Jamiolkowski, D. D. (1985) Polym. Prepr., 26 (2), 200.

    CAS  Google Scholar 

  43. Kricheldorf, H. R., Mang, T. and Jonte, J. M. (1984) Macromol., 17, 2173.

    Google Scholar 

  44. Pitt, C. G. (1984) J. Contr. Rel., 1, 3.

    Google Scholar 

  45. Huang, S. J. and Leong, K.-W. (1979) Polym. Prepr., 20, 552.

    Google Scholar 

  46. Huang, S. J., Bell, J. R., Knox, J. R.et al. (1977) in ACS Symp. Ser. No. 49 Textile and Paper Chemistry and Technology (ed. J. C. Arthur), p. 73.

    Google Scholar 

  47. Chvapil, M., Owen, J. A., Clark, D. S. et al. (1977) J. Biomed Mater. Res., 11, 297.

    Google Scholar 

  48. Dickenson, H. R., Hiltner, A., Gibbons, D. F. and Anderson, J. M. (1981) J. Biomed Mater. Res., 15, 577.

    Google Scholar 

  49. Dickenson, H. R. and Hiltner, A. (1981) J. Biomed Mater. Res., 15, 591.

    Google Scholar 

  50. Bruins, P. F. and Ashman, A. (1983) inProc. ANTEC 83 Soc. Plast. Eng.pp. 22–24.

    Google Scholar 

  51. Cameron, H. U., Macnab, I. and Pilliar, R. M. (1977) J. Biomed Res., 11, 179.

    Google Scholar 

  52. Gogolewski, S. and Pennings, A. J. (1982) Makromol. Chem., Rapid Commun., 3, 839.

    Google Scholar 

  53. Gogolewski, S., Pennings, A. L., Locomen, E.et al. (1983) Makromol. Chem. Rapid Commun. 4 213.

    Google Scholar 

  54. Gogolewski, S. and Pennings, A. J. (1983) Makromol. Chem., Rapid Commun, 4, 675.

    Article  CAS  Google Scholar 

  55. Yannis, I. V., Burke, J. F., Chen, E. et al. (1982) IUPAC Prepr., Amherst Mass., 336.

    Google Scholar 

  56. Leenslag, J.-W., Pennings, A. J., Veth, R. P. H.et. al. (1984) Makromol Chem. Rapid Commun.5, 815.

    Google Scholar 

  57. Leenslag, J. W., Gogolewski, S. and Pennings, A. J. (1984) J. Appl. Polym. Sci., 29, 2829.

    Article  CAS  Google Scholar 

  58. Currey, J. D. (1983) in Handbook of Composites, Vol. 4, (eds A. Kelly and Y. N. Rabotnov), Elsevier Science Publishers, Amsterdam, sect. 3. 2. 4.

    Google Scholar 

  59. Hyon, S.Y., Jamshidi, K., Ikada, Y. et al. (1985) Kobunshi Ronbun.,42(11), 771.

    Google Scholar 

  60. Tencer, A. F., Mooney, Brown, K. L. and Silva, P. A. (1985) J. Biomed. Mater. Res., 19 (8), 957.

    Article  CAS  Google Scholar 

  61. Corcoran, S. F., Koroluk, J. M., Parsons, J. R.et al. (1980) Current Concepts of Bone Fracture Fixation(ed. H. K. Uhthoff), Springer Verlag, Berlin, p. 136.

    Google Scholar 

  62. Alexander, H., Coreoran, S., Parsons, J. R. and Weiss, A. B. (1981) Bioeng., 9, 115.

    Google Scholar 

  63. Parsons, J. R., Alexander, H. and Weiss, A. B. (1983) Biocompatible Polymers, Metals and Composites, (ed. M. Szycher), Technomic Pub. Co., pp. 873–905.

    Google Scholar 

  64. Alexander, H., Parsons, J. R., Strauchler, I. D. and Weiss, A. B. (1983) US Patent No. 4, 411, 027.

    Google Scholar 

  65. Alexander, H., Weiss, A. B., Parsons, J. R. et al. (1979) Trans. ORS, 25th Ann. ORS, 4, 27.

    Google Scholar 

  66. Witvoet, J. and Christel, P. (1985) Clin. Orth. Rel. Res., 196, 143.

    Google Scholar 

  67. Bercovy, M., Gontallier, D., Voisin, M. C. et al. (1985) Clin. Orth. Rel. Res., 196, 159.

    CAS  Google Scholar 

  68. Alexander, H., Weiss, A. B., Parsons, J. R. et al. (1979) Trans. N. E Bioeng. Conf., 7, 400.

    Google Scholar 

  69. Aragona, J., Parsons, J. R., Alexander, H. and Weiss, A. B. (1981) Clin. Orthop., 160, 268.

    Google Scholar 

  70. Alexander, H., Strauchler, I., Weiss, A. B. et al. (1978) Trans. 4th Ann. Mtg. Soc. Biomat.123.

    Google Scholar 

  71. Getter, L., Cutright, D. E., Bhaskar, S. N. and Augsburg, J. K. (1972) J. Oral Surg., 30, 344.

    CAS  Google Scholar 

  72. Cutright, D. E. and Hunsuck, E. E. (1972) Oral Surg., 33(1), 28.

    Google Scholar 

  73. Christel, P., Chabot, F. and Vert, M. (1984) in2nd World Congr. Biomat. 10th Ann. Mtg. Soc. Biomat.279.

    Google Scholar 

  74. Schindler, A. and Pitt, C. G. (1984) Polym. Prepr., 25 (1), 257.

    Google Scholar 

  75. Casey, D. J. and Roby, M. S. (1984) US Pat No. 4, 429, 080.

    Google Scholar 

  76. Casey, D. J. and Roby, M. S. (1984) US Pat No. 4, 452, 973.

    Google Scholar 

  77. Chabot, F., Vert, M., Chapelle, S. and Granger, P. (1983) Polym., 24, 53.

    Article  CAS  Google Scholar 

  78. Huang, S. J, Edelman, P. G. and Cameron, J. A. (1987) inAdvances in Biomedical Polymers(ed. C. G. Gebelein), Plenum, pp. 101–109.

    Google Scholar 

  79. Huang, S. J. (1990) Polym. Mater. Sci. Eng., 63, 633.

    CAS  Google Scholar 

  80. Huang, S. J. (1985) Encyclopedia of Polymer Science and Engineering, 2, 2nd edn, John Wiley & Sons, New York, pp. 220–243.

    Google Scholar 

  81. Huang, S. J. (1989) in Comprehensive Polymer Science, Vol. 6 (eds G. Allen and J. C. Bevington), Pergamon Press, London, pp. 567–607.

    Google Scholar 

  82. Kaplan, D. L., Mayer, J. M., Ball, D. et al. (1993) in Biodegradable Polymers and Packaging (eds C. Ching, D. Kaplan and E. Thomas), Technomics Publishing, Lancaster-Basel, pp. 1–44.

    Google Scholar 

  83. Swift, G. (1993) Acc. Chem. Res., 26, 105.

    Article  CAS  Google Scholar 

  84. Lenz, R. (1993) in Advances in Polymer Series, Vol. 107 (eds N. A. Peppas and R. S. Langer ), Springer-Vierlanger, pp. 1–40.

    Google Scholar 

  85. Albertsson, A.-C. and Karlsson, S. (1993) in Comprehensive Polymer Science, First Supplement (eds G. A. Allen, S. L. Agarwal and S. Russo), Pergamon Press, London, p. 285.

    Google Scholar 

  86. Huang, J-C., Shetty, A. S. and Wang, M.-S. (1990) Adv. Polym. Technol., 10, 23.

    Article  CAS  Google Scholar 

  87. Dawes, E. A. and Senior, P. J. (1973) Adv. Micro. Physiol., 10, 135.

    Article  CAS  Google Scholar 

  88. Doi, Y. (1990) Microbial Polyesters, VCH, New York.

    Google Scholar 

  89. Anderson, A. J. and Dawes, E. A. (1990) Microbiol. Rev., 54, 450.

    CAS  Google Scholar 

  90. Homes, P. A., Collins, S. H. and Wright, L. F. (1984) US Pat. No. 4,477, 654.

    Google Scholar 

  91. Steinbüchel, A. (1991) Biomaterials: Novel Materials from Biological Sources, Stockton Press, New York, pp. 123–214.

    Google Scholar 

  92. Brandly, H., Gross, R. A., Lenz, W. R. and Fuller, R. C. (1990) Adv. Biochem. Eng. Biotech., 41, 77.

    Google Scholar 

  93. Marchessault, R. H., Blulim, T. L., Deslandes, Y. et al. (1988) Makromol. Chem. Makromol. Symp.,19, 235.

    Google Scholar 

  94. Doi, Y., Kanesawa, Y., Kunioka, M. and Saito, T. (1990) Macromolecules, 23, 26.

    Article  CAS  Google Scholar 

  95. Kawaguchi, Y. and Doi, Y. (1992) Macromolecules, 25, 2324.

    Article  CAS  Google Scholar 

  96. Jendrossek, D., Knoke, L, Habibian, R. B. et al. (1993) J. Environ. Polym Deg.,1(1)53.

    Google Scholar 

  97. Nishida, H. and Tokiwa, Y. (1993) J. Environ. Polym. Deg., 1 (1), 65.

    Article  CAS  Google Scholar 

  98. Nishida, H. and Tokiwa, Y. (1993) J. Environ. Polym. Deg., 1 (3), 235.

    Article  Google Scholar 

  99. Buchanan, C. M., Gardner, R. M. and Komarek, R. J. (1993) J. Appl. Polym. Sci., 47, 1709.

    Article  CAS  Google Scholar 

  100. Gu, J.-D., Eberiel, D. T., McCarthy, S. P. and Gross, R. A. (1993) J. Environ. Polym. Deg., 1 (2), 143.

    Article  CAS  Google Scholar 

  101. Chum, H. L. (ed.) (1989) Biobased Materials, Report SERI/TR-234–3610, Solar Energy Research Institute, Colorado, pp. 1–12.

    Google Scholar 

  102. Rossall, B. (1974) Ind. Biodeterioration Bull., 10, 95.

    CAS  Google Scholar 

  103. Arthur, J. Jr., (1985) in Celluslose and Its Derivatives (eds J. F. Kennedy and G. O. Phillips ), Ellis Horwood Chichester.

    Google Scholar 

  104. Assempour, H., Koenig, M. F. and Huang, S. J. in Unconventional and Nonfood Uses of Agricultural Biopolymers (eds M. L. Fishman, R. B. Friedman and S. J. Huang), ACS Symposium Series, in press.

    Google Scholar 

  105. Corti, A., Vallini, G., Pera, A. et al. (1992) in Biodegradable Polymers and Plastics,(eds M. Vert, J. Feijeu, A. Albertsson et al.),Royal Society of Chemistry, pp. 245248.

    Google Scholar 

  106. Bastioli, C., Bellotti, V., Del Giudice, L. and Gilli, G. (1992) in Biodegradable Polymers and Plastics,(eds M. Vert, J. Feijen, A. Albertsson et al.),Royal Society of Chemistry, pp. 101–111.

    Google Scholar 

  107. Bastioli, C., Bellotti, V., Del Giudice, L. and Gilli, G. (1993) J. Environ. Polym. Deg., 1 (3), 181.

    Article  CAS  Google Scholar 

  108. Szivek, J. A., Weatherly, G. C., Pilliar, R. M. and Cameron, H. U. (1981) J. Biomed. Res., 15, 853.

    Google Scholar 

  109. Brown, S. A. and Mayor, M. B. (1978) J. Biomed Res., 12, 67.

    Article  CAS  Google Scholar 

  110. Woo, S. L-Y., Akeson, W. H., Levenetz, B. et al. (1974) J. Biomed. Mater. Res., 8, 321.

    Google Scholar 

  111. Gourlay, S. J., Rice, R. M., Hegycli, A. F. et al. (1978) J. Biomed Mater. Res., 12, 219.

    Google Scholar 

  112. Rice, R. M., Hegyeli, A. F., Gourlay, S. J. et al. (1978) J. Biomed. Mater. Res., 12, 43.

    Google Scholar 

  113. Huang, S. J., Bitritto, M., Leong, K. W. et al. (1978) in Adv. Chem. Ser. No. 169, Stabilization and Degradation of Polymers, (eds D. L. Allara and W. L. Hawkins ), American Chemical Society, p. 205.

    Google Scholar 

  114. Huang, S. J. and Roby, M. S. (1986) J. Bioact. Compas. Polym., 1, 61.

    Article  CAS  Google Scholar 

  115. Gilding, D. K. (1982) in Biocompatibility of Clinical Implant Materials, Vol. II, (ed. D. F. Williams), CRC Press, Boca Raton.

    Google Scholar 

  116. Heller, J. (1983) Initiation of Polymerization,(ed. F. E. Bailey), ACS Symp. Ser. No. 212, p. 373.

    Google Scholar 

  117. Huang, S. J. (1985) in Encyclopedia of Polymer Science and Engineering, (eds.) Mark, Bikales, Overberger and Menges, V. 2, 2nd Ed., 1985, pp. 220–244.

    Google Scholar 

  118. Williams, D. F. (1982) J. Mater. Sci., 17, 1233.

    Article  CAS  Google Scholar 

  119. Huang, S. J., Bansleben, D. A. and Knox, J. R. (1979) J. Appl. Polym. Sci., 23, 429.

    Article  CAS  Google Scholar 

  120. Huang, S. J., Bell, J. P., Knox, J. R. et al. (1976) Proc 3rd Int. Biodeg. Symp., (eds J. M. Sharpley and A. M. Kaplan), Applied Science Publishers, London, p. 73 1.

    Google Scholar 

  121. Bitritto, M. M., Bell, J. P., Brenkle, G. M.et al. (1979) J. Appl. Polym. Sci Appl. Polym. Symp. 35 405.

    Google Scholar 

  122. Bell, J. P., Huang, S. J. and Knox, J. R. (1974) TR 75–48-CEMEL, US Army, Natick Laboratory, Natick, Mass.

    Google Scholar 

  123. Williams, D. J. (1980) J. Biomed Mater. Res., 14, 329.

    Article  CAS  Google Scholar 

  124. Chu, C. C. (1981) J. Biomed Mater. Res., 15, 19.

    Article  CAS  Google Scholar 

  125. Chu, C. C. and Louie, M. (1985) J. Appl. Polym Sci., 30, 3133.

    Article  CAS  Google Scholar 

  126. Huffman, K. R. and Casey, D. J. (1985) J. Polym. Sci., Polym. Chem. Ed., 23, 1939.

    Article  CAS  Google Scholar 

  127. Chu, C. C. (1985) Polym., 26, 591.

    Article  CAS  Google Scholar 

  128. Murphy, C. A., Cameron, J. A., Huang, S.J., and Vinopal, R. T., (1996), Appl. Environ. Microbiol., 456.

    Google Scholar 

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Huang, S.J. (2002). An Overview of Biodegradable Polymers and Biodegradation of Polymers. In: Scott, G. (eds) Degradable Polymers. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1217-0_2

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