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Modeling Aerosol Drug Delivery

  • Conference paper
Optimization of Aerosol Drug Delivery

Abstract

Delivery of a therapeutic agent by inhalation has seen increasing applications for many respiratory diseases, including asthma, COPD, and allergies. Aerosol delivery has advantages: it delivers medication directly to where it is needed, and it avoids the first-pass effect with minimum reduction of bioavailability. More recently, the inhalation route has been extensively researched as an alternative for systematic administration of proteins and peptides because of the large surface area in the pulmonary region and rapid absorption of the delivered drug from the alveolar region to the blood. Aerosol delivery is non-invasive and is effective in much lower doses than required for oral administration. Currently, there are several types of therapeutical aerosol delivery systems, including the pressurized metered dose inhaler (pMDI), the dry powder inhaler (DPI), the medical nebulizer, the solution mist inhaler, and nasal sprays.

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Author information

Authors and Affiliations

  1. Lovelace Respiratory Research Institute, Albuquerque, NM, USA

    Yung Sung Cheng

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  1. Yung Sung Cheng
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Editor information

Editors and Affiliations

  1. University of Technology, Warsaw, Poland

    Leon Gradoń

  2. Faculty of Appplied Sciences, Delft University of Technology, Delft, The Netherlands

    Jan Marijnissen

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© 2003 Springer Science+Business Media Dordrecht

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Cheng, Y.S. (2003). Modeling Aerosol Drug Delivery. In: Gradoń, L., Marijnissen, J. (eds) Optimization of Aerosol Drug Delivery. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0267-6_10

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  • DOI: https://doi.org/10.1007/978-94-017-0267-6_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6436-3

  • Online ISBN: 978-94-017-0267-6

  • eBook Packages: Springer Book Archive

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