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Potassium Channels; Genes, Proteins, and Patients

  • Chapter
Cardiovascular Specific Gene Expression

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 214))

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Abstract

Potassium (K+) channels play a major role in generating cardiac electrical activity. Cardiac action potentials are characterized by a long duration which is pivotal for proper contraction. In physiological conditions the repolarization process is largely determined by several potassium channels with different time and voltage characteristics. These channels are distributed heterogeneously over different parts of the heart. In addition, developmental changes in channel diversity are pertinent. Furthermore, under the influence of a variety of stimuli, which include metabolic changes, neurohumoral influences and disease, the set of expressed potassium channels may change. In pathophysiological conditions such as cardiac hyperthrophy and/or heart failure, altered characteristics of potassium channels usually lead to prolonged repolarization. Arrhythmias ensue, based on either dispersion in repolarization or reexcitation during the course of the action potential (afterdepolarizations and triggered activity).

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Authors
  1. Connie Alshinawi
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  2. Arthur A. M. Wilde
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Editor information

Editors and Affiliations

  1. Department of Cardiology, Academic Hospital Maastricht, Maastricht, The Netherlands

    Pieter A. Doevendans

  2. Academic Hospital Maastricht, CARIM, Maastricht, The Netherlands

    Robert S. Reneman

  3. Department of Physiology, Academic Hospital Maastricht, Maastricht, The Netherlands

    Marc van Bilsen

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© 1999 Springer Science+Business Media Dordrecht

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Alshinawi, C., Wilde, A.A.M. (1999). Potassium Channels; Genes, Proteins, and Patients. In: Doevendans, P.A., Reneman, R.S., van Bilsen, M. (eds) Cardiovascular Specific Gene Expression. Developments in Cardiovascular Medicine, vol 214. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9321-2_14

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  • DOI: https://doi.org/10.1007/978-94-015-9321-2_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5189-9

  • Online ISBN: 978-94-015-9321-2

  • eBook Packages: Springer Book Archive

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