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Cardiovascular Specific Gene Expression

  • Book
  • © 1999

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Editors:
  1. Pieter A. Doevendans

    1. Department of Cardiology, Academic Hospital Maastricht, Maastricht, The Netherlands

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    You can also search for this editor in PubMed   Google Scholar

  2. Robert S. Reneman

    1. Academic Hospital Maastricht, CARIM, Maastricht, The Netherlands

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    You can also search for this editor in PubMed   Google Scholar

  3. Marc Bilsen

    1. Department of Physiology, Academic Hospital Maastricht, Maastricht, The Netherlands

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 214)

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Cardiology Approaching the Year 2000. A Clinician’s Look at Molecular Cardiology

    1. Cardiology Approaching the Year 2000. A Clinician’s Look at Molecular Cardiology

      • Hein J. J. Wellens
      Pages 1-5

  3. Cardiovascular specific gene expression

    1. The Transcriptional Building Blocks of the Heart

      • Diego Franco, Robert Kelly, Peter Zammit, Margaret Buckingham, Antoon F. M. Moorman
      Pages 7-16

    2. A Cardiac-Specific Troponin I Promoter. Distinctive Patterns of Regulation in Cultured Fetal Cardiomyocytes, Adult Heart and Transgenic Mice

      • Stefano Schiaffino, Simonetta Ausoni, Caterina Millino, Elisa Calabria, Claudia Sandri, Raffaella Di Lisi
      Pages 17-25

    3. Mice Deficient in Muscle LIM Protein (MLP) Reveal a Pathway to Dilated Cardiomyopathy and Heart Failure

      • Pico Caroni
      Pages 27-33

    4. Regulation of Endothelial Cell Specific Receptor Tyrosine Kinase Gene Expression during Development and Disease

      • Thorsten M. Schlaeger
      Pages 35-48

    5. Smoothelins: One Gene, Two Proteins, Three Muscle Cell Types .... so Far

      • Guillaume J. J. M. van Eys, Carlie J. M. de Vries, Sander S. M. Rensen, Victor L. J. L. Thijssen, Edward L. C. Verkaar, Gisela P. G. M. Coolen et al.
      Pages 49-66

  4. Transcription regulation

    1. Regionalization of Transcriptional Potential in the Myocardium: ‘Cardiosensor’ Transgenic Mice

      • Robert G. Kelly, Peter S. Zammit, Diego Franco, Antoon F. M. Moorman, Margaret E. Buckingham
      Pages 67-73

    2. Human Troponin Genes: Transcriptional Regulation and Chromosomal Organization

      • Paul J. R. Barton, Pankaj K. Bhavsar, Kimberley A. Dellow, Philip J. Townsend, Magdi H. Yacoub, Nigel J. Brand
      Pages 75-86

    3. Retinoid Signaling: Insight from Genetically Engineered Mice

      • Pilar Ruiz-Lozano, Kenneth R. Chien
      Pages 87-97

    4. Ventricular Expression of the Atrial Regulatory Myosin Light Chain Gene

      • Pieter A. Doevendans, Ronald Bronsaer, Pilar Ruiz-Lozano, Jan Melle van Dantzig, Marc van Bilsen
      Pages 99-116

    5. Expression of Rat Gap Junction Protein Connexin 40 in the Heart

      • W. Antoinette Groenewegen
      Pages 117-124

  5. Ion channels and gap junction

    1. Sympathetic Regulation of Cardiac Delayed Rectification: Relationship to Cardiac Arrhythmias

      • Robert S. Kass
      Pages 125-137

    2. The Sarco(Endo)Plasmic Reticulum Ca2+ Pumps in the Cardiovascular System

      • Anne-Marie Lompré, Olivier Vallot, Marielle Anger, Anne Ozog
      Pages 139-150

    3. Potassium Channels; Genes, Proteins, and Patients

      • Connie Alshinawi, Arthur A. M. Wilde
      Pages 151-160

    4. Expression of Cx43 in Cardiac and Aortic Muscle Cells of Hypertensive Rats

      • Jacques-Antoine Haefliger, Paolo Meda
      Pages 161-169

    5. Genetic Engineering and Cardiac Ion Channels

      • Andrew A. Grace, Richard C. Saumarez, Jamie I. Vandenberg
      Pages 171-178

  6. Intracellular signaling

    1. Receptor Tyrosine Kinase Signaling in Vasculogenesis and Angiogenesis

      • Thomas I. Koblizek, Werner Risau, Urban Deutsch
      Pages 179-191

    2. Molecular Analysis of Vascular Development and Disorders

      • Peter Carmeliet, Désiré Collen
      Pages 193-225

    3. Crosstalk between the Estrogen Receptor and the Insulin-Like Growth Factor (IGF-1) Receptor. Implications for Cardiac Disease

      • Christian Grohé, Rainer Meyer, Hans Vetter
      Pages 227-235
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Keywords

About this book

Improving our insights into the genetic predisposition to cardiovascular disease is one of the most important challenges in our field in the next millennium, not only to unravel the cause of disease but also to improve the selection of patients for particular treatments. Nowadays, for example, subjects with a cholesterol above a particular plasma level are exposed to a cholesterol lowering regime based upon the beneficial outcome of epidemiological studies which include subjects not prone to the disease, despite a plasma cholesterol above the accepted level. Identification of the patients who are genetically predisposed to the consequences of this disorder will reduce the number of subjects unnecessarily treated and, hence, the costs of health care. Because in most cardiovascular diseases the genetic component is a consequence of more than one gene defect, only limited progress has as yet been made in identifying subjects genetically at risk. For example, in hypertension only in less than 10% of the patients the genetic defect has been identified. It has been known for quite some time that in heart and blood vessels fetal genes are as high blood pressure and upregulated or induced when they are exposed to such disorders ischemia. Little is known about the function of these genes in the cardiac and vascular adaptation to these disorders; only guesses can be made.

Editors and Affiliations

  • Department of Cardiology, Academic Hospital Maastricht, Maastricht, The Netherlands

    Pieter A. Doevendans

  • Academic Hospital Maastricht, CARIM, Maastricht, The Netherlands

    Robert S. Reneman

  • Department of Physiology, Academic Hospital Maastricht, Maastricht, The Netherlands

    Marc Bilsen

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