Abstract
The natural prostaglandins are intimately associated with a formidable array of physiological processes1. Not unexpectedly, the administration of these compounds usually elicits a complex spectrum of physiological and pharmacological responses. Some of the naturally occurring prostaglandins such as PGE1, E2, F2α have been synthesized and are currently available for clinical use1,2; however, the routine use of natural prostaglandins as therapeutic agents is limited by their chemical instability, lack of target tissue specificity, and rapid metabolic inactivation3. For ideal use, orally administered prostaglandins should remain available in therapeutic levels for several hours after ingestion, act on specific selected tissues, produce a minimum of undesirable effects, and have acceptable pharmaceutical stability. These challenges have been met with less than uniform degrees of success. The purpose of this chapter is to review the bioregulation, modes of action and the development of the analogues of prostaglandins in the field of obstetrics and gynaecology.
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Kimball, F.A., Kirton, K.T. (1986). Bioregulation and mode of action. In: Bygdeman, M., Berger, G.S., Keith, L.G. (eds) Prostaglandins and their Inhibitors in Clinical Obstetrics and Gynaecology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6734-5_1
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DOI: https://doi.org/10.1007/978-94-011-6734-5_1
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