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Immunodeficiency diseases — a review

  • Chapter
Inborn Errors of Immunity and Phagocytosis

Abstract

Recent years have witnessed a great surge in understanding immunological function in both cellular and molecular terms. This increased knowledge has permitted definition of the two major arms of the immunity system as cells that develop under thymic influence or under an alternative influence that is exercised by the bursa of Fabricius in birds (the T and B cell systems). Major aspects of the biological amplification systems by which the specific immunological adaptation can address the fundamental effector processes have also been recognized. Increasingly, these have been defined in precise molecular terms by chemical and immunological means. The fundamental effector processes are also beginning to be understood precisely in both cellular and molecular terms. Thus the complement system is now very well defined, lymphokines are increasingly well understood and the processes that underlie and effect phagocytosis, inflammation, vascular reactivity and blood coagulation are being analysed and defined with increasing precision.

Aided by Public Health Service Research Grants CA-19267, CA-08748 and CA-17404 from the NCI; by the Zelda R. Weintraub Cancer Fund, the Judith Harris Selig Memorial Fund, and the Charles E. Merrill Trust.

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Authors
  1. R. N. Pahwa
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  2. S. G. Pahwa
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  3. R. O’Reilly
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  4. Elizabeth M. Smithwick
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  5. R. A. Good
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Editor information

Editors and Affiliations

  1. John F. Kennedy Institute, DK-2600, Glostrup, Denmark

    F. Güttler

  2. Department of Chemical Pathology, Institute of Child Health, WC1N 1EH, London

    J. W. T. Seakins

  3. Division of Perinatal Medicine, MRC Clinical Research Centre, Harrow, HA1 3UJ, Middlesex, London

    R. A. Harkness

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© 1979 The Society for the Study of Inborn Errors of Metabolism

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Pahwa, R.N., Pahwa, S.G., O’Reilly, R., Smithwick, E.M., Good, R.A. (1979). Immunodeficiency diseases — a review. In: Güttler, F., Seakins, J.W.T., Harkness, R.A. (eds) Inborn Errors of Immunity and Phagocytosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6197-8_1

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  • DOI: https://doi.org/10.1007/978-94-011-6197-8_1

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