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Raloxifene HCl: A Tissue Selective Estrogen Receptor Modifier (SERM) for Replacement Therapy in Postmenopausal Women

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Women’s Health and Menopause

Part of the book series: Medical Science Symposia Series ((MSSS,volume 11))

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Abstract

Chronic estrogen deficiency is a major cause of morbidity and mortality among postmenopausal women. The most compelling sequelae are coronary artery disease and osteoporotic fractures, but other effects related to loss of estrogen can seriously impair quality of life[1,2].

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References

  1. Honjo H, Tanaka H, Kashiwagi T, et al. Senile dementia—Alzheimer’s type and estrogen. Hormone Metab Res 1995;27:204–7.

    Article  CAS  Google Scholar 

  2. Kauffman RF, Bryant HU. Selective estrogen receptor modulators. Drug News and Perspectives 1995;8:531–39.

    Google Scholar 

  3. Compston JE. HRT and osteoporosis. Br Med Bull 1992:48:309–44.

    PubMed  CAS  Google Scholar 

  4. Writing Group for the PEPI Trial. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The postmenopausal estrogen/progestin interventions (PEPI) trial. JAMA 1995;273:199–208.

    Article  Google Scholar 

  5. Colditz GA, Hankinson SE, Hunter DJ, et al. The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med 1995;332:1589–93.

    Article  PubMed  CAS  Google Scholar 

  6. Hammond CB. Women’s concerns with hormone replacement therapy—compliance issues. Fertil Steril 1994;62(Suppl 2):157S–160S.

    PubMed  CAS  Google Scholar 

  7. Data on file, Lilly Research Laboratories.

    Google Scholar 

  8. Draper MW, Flowers DE, Huster WJ, Neild JA, Harper D, Arnaud C. A controlled trial of raloxifene (LY139481) HCl: Impact on bone turnover and serum lipid profile in healthy postmenopausal women. J Bone Miner Res 1996; 11:835–42.

    Article  PubMed  CAS  Google Scholar 

  9. Morii H, Orimo M, Takani Y, et al. Effect of raloxifene hydrochloride on postmenopausal Japanese women with osteoporosis. J Bone Miner Res 1996;11(Suppl 1):S446 (abstr T588).

    Google Scholar 

  10. Manson JE. Postmenopausal hormone therapy and atherosclerotic disease. Am Heart J 1994; 128:1337–43.

    Article  PubMed  CAS  Google Scholar 

  11. Fuchs-Young R, Glasebrook AL, Short LL, et al. Raloxifene is a tissue selective agonist/ antagonist that functions through the estrogen receptor. Ann NY Acad Sci 1995;761:355–60.

    Article  PubMed  CAS  Google Scholar 

  12. Kleinman D, Karas M, Danilenko M, et al. Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-1 induced tyrosine phosphorylation and reduction in IGF binding proteins. Endocrinology 1996;137:1089–95.

    Article  PubMed  CAS  Google Scholar 

  13. Anzano MA, Peer CW, Smith JM, et al. Chemoprevention of mammary carcinogenesis in the rat: Combined use of raloxifene and 9-cis-retinoic acid. J Natl Cancer Inst 1996;88:123–25.

    Article  PubMed  CAS  Google Scholar 

  14. Yang NN, Venugopalan M, Hardikar S, Glasebrook A, et al: Identification of an estrogen response element activated by metabolites of 17β-estradiol and raloxifene. Science 1996;273: 1222–25.

    Article  PubMed  CAS  Google Scholar 

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© 1997 Springer Science+Business Media Dordrecht

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Termine, J.D. (1997). Raloxifene HCl: A Tissue Selective Estrogen Receptor Modifier (SERM) for Replacement Therapy in Postmenopausal Women. In: Paoletti, R., Crosignani, P.G., Kenemans, P., Samsioe, G., Soma, M.R., Jackson, A.S. (eds) Women’s Health and Menopause. Medical Science Symposia Series, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5560-1_45

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  • DOI: https://doi.org/10.1007/978-94-011-5560-1_45

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6343-2

  • Online ISBN: 978-94-011-5560-1

  • eBook Packages: Springer Book Archive

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