Abstract
Depression is more common in women than men regardless of whether one looks at community studies, hospital admission data, suicide attempts, or prescriptions for antidepressants. The dilemma is to determine is how much this excess in depression, particularly at the menopause, is due to the hormonal characteristics of the woman rather than the other environmental, domestic, or sociological factors which may be more stressful in women than men. The latter would be the view of most psychologists and the view of politically correct feminists, but ignores the fact that increased depression occurs at times of hormonal fluctuation such as during the years of the climacteric.
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References
Magos AL, Brincat M, Studd JWW. Treatment of the premenstrual syndrome by subcutaneous oestradiol implants and cyclical oral norethisterone: Placebo Controlled Study. Br Med J 1986;292:1629–33.
Watson NR, Studd JWW, Savvas M, et al. Treatment of severe premenstrual syndrome with oestradiol patches and cyclical oral norethisterone. Lancet 1989;i:730–34.
Gregoire AJP, Kumar R, Everitt B, Henderson AF, Studd JWW. Transdermal oestrogen is an effective treatment for severe postnatal depression. Lancet 1996;347:930–33.
Montgomery JC, Brincat M, Studd JWW, et al. Effect of oestrogen and testosterone implants on psychological disorders in the climacteric. Lancet 1987;i:297–99.
Studd JWW, Panay N. Chronic fatigue syndrome. Lancet 1996;348:1384.
Maggi A, Perez J. Role of female gonadal hormones in the CNS: Clinical and experimental aspects. Life Sciences 1985;37:893–906.
Sherwin BB. Hormones, mood and cognitive functioning in postmenopausal women. Obstet Gynaecol 1996;87(2S):20–26.
Crowley WR. Effects of ovarian hormones on norepinephrine and dopamine turnover in individual hypothalamic and extrahypothalamic nuclei. Neuroendo-crinology 1982;34:381–86.
Luine VN, McEwen BS. Effect of estradiol on turnover of type A monoamine oxidase in brain. J Neurochem 1977;28:1221–27.
Aylward M. Plasma tryptophan levels and mental depression in postmenopausal subjects. Effects of oral piperazine oestrone sulphate. IRCS Med Sci 1973;1:30–34.
Day E, Gray A, Barlow D, et al. Measuring the impact of menopausal symptoms on Quality of Life. Br Med J 1993:307:836–40.
Limouzin-Lamothe M, Mairon N, LeGal J, et al. Quality of life after the menopause: Influence of hormone replacement therapy. Am J Obstet Gynaecol 1991;78(Pt6):991–95.
Ditkoff EC, Crary WG, Cristo M, Lobo RA. Estrogen improves psychological functioning in asymptomatic postmenopausal women. Obstet Gynaecol 1991;78:991–95.
Best N, Rees M, Barlow D, et al. Effect of estradiol implants on noradrenergic function and mood in menopausal patients. Psychoneurendocrinology, 1992;17(Pt1):87–93.
Klaiber EL, Broverman DM, Vogel W, et al. Estrogen replacement therapy for severe persistent depression in women. Arch Gen Psych 1979;36:550–54.
Magos AL, Brewster E, Studd JWW, et al. The effects of norethisterone in postmenopausal women on oestrogen replacement therapy: A model for premenstrual syndrome. Br J Obstet Gynaecol 1986;93:1290–96.
Studd JWW. Complications of hormone replacement therapy in post-menopausal women. JR Soc Med 1992;85:376–78.
Raudaskoski TH, Lahti EI, Kauppila AJ, et al. Transdermal estrogen with a levonorgestrel-releasing intrauterine device for climacteric complaints: Clinical and endometrial responses. Am J Obstet Gynaecol 1995;172:114–19.
Suhonen SP, Holmstrom T, Allonen HO, et al. Intrauterine and sub-dermal progestin administration in postmenopausal hormone replacement therapy. Fertil Steril 1995;63:336–42.
Panay N, Studd JWW, Thomas A, et al. The levonorgestrel intrauterine system as progestogenic opposition for oestrogen replacement therapy. Presentation at The 8th International Congress on The Menopause, Sydney. 1996.
Studd JWW, Collins WP, Chakravarti S, Newton JR, Oram D, Parsons A. Oestradiol and testosterone implants in the treatment of psychosexual problems in the postmenopausal woman. Br J Obstet Gynaecol 1977;84:314–15.
McCoy N, Davidson JM. A longitudinal study of the effects of menopause on sexuality. Maturitas 1985;7:203.
Myers LS, Dixen J, Morrissette M, Carmichael M, Davidson JM. Effects of estrogen, androgen and progestin on sexual psychophysiology and behavior in postmenopausal women. J Clin Endocrinol Metab 1990;70:1124–31.
Burger H, Hailes J, Nelson J, Menelaus M. Effect of combined implants of estradiol and testosterone on libido in postmenopausal women. Br Med J 1984;294:936–37.
Davis SR, McCloud P, Strauss BJG, Burger H. Testosterone enhances estradiol’s effects on postmenopausal bone density and sexuality. Maturitas 1994;21:227–36.
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Studd, J., Panay, N. (1997). Hormone Replacement Therapy in the Prevention and Treatment of Climacteric Depression. In: Paoletti, R., Crosignani, P.G., Kenemans, P., Samsioe, G., Soma, M.R., Jackson, A.S. (eds) Women’s Health and Menopause. Medical Science Symposia Series, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5560-1_27
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DOI: https://doi.org/10.1007/978-94-011-5560-1_27
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