Abstract
There is epidemiological evidence that estrogen and combined hormone replacement therapy (HRT) in postmenopausal women could be useful for the prevention of cardiovascular disease. On reaching the theoretical perimenopausal age, some women begin a hormone replacement therapy without cessation of menses. Many of them switch from long-time use of oral contraceptives directly to HRT (TRANS). The aim of the present study was to establish the advantage of such an early preventive use of HRT for the lipoprotein profile, glucose metabolism, and blood coagulation-fibrinolysis system.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Krappweis J, Schwarz U, Kirch W. Der Arzneimittelgebrauch bei Frauen im Bundesland Sachsen auf der Grundlage von Survey-Daten. Gesundheitswesen 1996;2:115–19.
Folsom AR, Kaye SA, Sellers TA, et al. Body fat distribution and 5-year risk of death in older women. JAMA 1993;269:483–87.
Campos H, McNamara JR, Wilson PWF. Differences in low density lipoprotein subfractions and apolipoproteins in premenopausal and postmenopausal women. J Clin Endocrinol Metab 1988;67:30–35.
Stevenson JC, Crook D, Godsland IF. Influence of age and menopause on serum lipids and lipoproteins in healthy women. Atherosclerosis 1993;98:83–90.
Jensen J, Nilas L, Christianson C. Influence of the menopause on serum lipids and lipoproteins. Maturitas 1990;12:321–25.
Fukami K, Koike K, Hirota K, Yoshikawa H, Miyake A. Perimenopausal changes in serum lipids and lipoproteins: A 7-year longitudinal study. Maturitas 1995;22:193–97.
Barrett-Connor E, Laakso M. Ischemic heart disease risk in postmenopausal women: Effects of estrogen use on glucose and insulin levels. Arteriosclerosis 1990;10:531–34.
Matthews KA, Wing RR, Kuller LH, Meilahn EN, Plantinga P. Influence of perimenopause on cardiovascular risk factors and symptoms of middle-aged healthy women. Arch Intern Med 1994;154:2349–55.
Pansini F, Bonaccorsi G, Calisesi M. Influence of spontaneous and surgical menopause on atherogenic metabolic risk. Maturitas 1993;17:181–90.
Salomaa V, Rasi V, Pekkanen J, et al. Association of hormone replacement therapy with hemostatic and other cardiovascular risk factors the FINRISK hemostasis study. Arteriosclerosis Thrombosis and Vascular Biology 1995;15:1549–55.
Meilahn EN, Kuller LH, Matthews KA, Kiss JE. Hemostatic factors according to menopausal status and use of hormone replacement therapy. Ann Epidemiol 1992;2:445–55.
Siegelt G, Bergmann S, Jaross W, Assmann G. Abhängigkeit der Hämostase-parameter Fibrinogen, Plasminogenaktivatorinhibitor und Antithrombin III von Alter und Geschlecht sowie ihre Beziehung zu bekannten Risikofaktoren der Atherosklerose in der Bevölkerung von Dresden und Umgebung (Drecan-Studie). Klin Lab 1992;38:499–505.
Gaspard UJ, Gottal J-M, Brule FA van den. Postmenopausal changes in lipid and glucose metabolism: A review of their main aspect. Maturitas 1995;21:171–78.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Bergmann, S., Mix, C., Siegert, G., Uhlig, C., Richter, P., Jaross, W. (1997). Which Effects Does Early HRT Have on Perimenopausal Changes in the Lipoprotein Profile, Glucose Metabolism, and the Blood Coagulation-Fibrinolysis System?. In: Paoletti, R., Crosignani, P.G., Kenemans, P., Samsioe, G., Soma, M.R., Jackson, A.S. (eds) Women’s Health and Menopause. Medical Science Symposia Series, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5560-1_21
Download citation
DOI: https://doi.org/10.1007/978-94-011-5560-1_21
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6343-2
Online ISBN: 978-94-011-5560-1
eBook Packages: Springer Book Archive