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Some evolutionary consequences of deleterious mutations

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Mutation and Evolution

Part of the book series: Contemporary Issues in Genetics and Evolution ((CIGE,volume 7))

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Abstract

Most mutations with observable phenotypic effects are deleterious. Studies of Drosophila and inbred plant populations suggest that a new individual may have a mean number of new deleterious mutations that exceeds one-half. Most of these have relatively small homozygous effects and reduce fitness by 1–2% when heterozygous. Several striking features of present-day organisms have apparently evolved in response to the constant input of deleterious alleles by recurrent mutation. For example, the adaptations of hermaphroditic organisms for outcrossing have been widely interpreted in terms of the benefits of avoiding the reduced fitness of inbred progeny, which is partly due to deleterious mutations. Population genetic models of modifiers of the breeding system in the presence of genome-wide deleterious mutation are reviewed and their predictions related to genetic and comparative data. The evolution of degenerate Y chromosomes is a phenomenon that may be caused by the accumulation of deleterious mutations. The population genetic mechanisms that can drive this degeneration are reviewed and their significance assessed in the light of available data.

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  1. Brian Charlesworth & Deborah Charlesworth

    Present address: ICAPB, Ashworth Laboratories, University of Edinburgh, Edinburgh, EH9 3JT, UK

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  1. Department of Ecology and Evolution, University of Chicago, 1101, E. 57th St., Chicago, IL, 60637-1573, USA

    Brian Charlesworth & Deborah Charlesworth

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  1. Bowling Green State University, Bowling Green, Ohio, USA

    Ronny C. Woodruff

  2. University of Oklahoma, Norman, Oklahoma, USA

    James N. Thompson Jr.

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Charlesworth, B., Charlesworth, D. (1998). Some evolutionary consequences of deleterious mutations. In: Woodruff, R.C., Thompson, J.N. (eds) Mutation and Evolution. Contemporary Issues in Genetics and Evolution, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5210-5_1

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  • DOI: https://doi.org/10.1007/978-94-011-5210-5_1

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