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P element regulation and X-chromosome subtelomeric heterochromatin in Drosophila melanogaster

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Evolution and Impact of Transposable Elements

Part of the book series: Contemporary Issues in Genetics and Evolution ((CIGE,volume 6))

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Abstract

In Drosophila melanogaster, crossing males carrying autonomous P elements with females devoid of P copies results in hybrid dysgenesis in the germline of progeny. The reciprocal cross produces non-dysgenic progeny due to a maternally inherited state non-permissive for P transposition. the capacity of a P copy to repress transposition depends on both its structure and its chromosomal location. Naturally occuring regulatory P elements inserted at the telomere of the X chromosome have been genetically isolated in a genomic context devoid of other P elements. One or two copies of autonomous P elements at this site (1A) are sufficient to elicit a strong P repression in the germline. These elements are flanked by Telomeric Associated Sequences, previously identified and described by Karpen and Spradling (1992) as having heterochromatic properties. the regulatory properties of P elements at 1A are strongly impaired by mutations affecting Su(var)205, which encodes Heterochromatin Protein 1, a non-histone heterochromatin protein. the regulatory properties of classical P strains are not sensitive to Su(var)205. Models based on chromatin structure or on nuclear localisation of the telomeres are discussed in order to explain both the strong regulatory properties of P elements at the X chromosome telomere and their sensitivity to Su(var)205.

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Authors and Affiliations

  1. Département Dynamique du Génome et Evolution, Institut Jacques Monod, UMR9922 CNRS-Université Denis Diderot, 2 place Jussieu, 75251, Paris Cedex 05, France

    Stéphane Ronsseray, Monique Lehmann, Danielle Nouaud & Dominique Anxolabéhère

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  1. Stéphane Ronsseray
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  2. Monique Lehmann
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  3. Danielle Nouaud
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  4. Dominique Anxolabéhère
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Pierre Capy

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Ronsseray, S., Lehmann, M., Nouaud, D., Anxolabéhère, D. (1997). P element regulation and X-chromosome subtelomeric heterochromatin in Drosophila melanogaster . In: Capy, P. (eds) Evolution and Impact of Transposable Elements. Contemporary Issues in Genetics and Evolution, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4898-6_9

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  • DOI: https://doi.org/10.1007/978-94-011-4898-6_9

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