Abstract
An attempt has been made in the present paper to review our current knowledge on the feasibility of developing on FSH based male contraceptive vaccine for male contraception. Both monkey and man respond to oFSH vaccine in a similar manner by producing high affinity antibodies capable of bioneutralizing primate FSH action. No changes in the serum testosterone and T3/ T4 were observed. Active immunization of monkeys with oFSH for more than 120 days results in oligospermia, significant reduction in fertility index and infertility as demonstrated by actual mating studies. Sertoli cell function of both monkey and man was affected by FSH immunization. Immunization of man with oFSH, albeit for 70 days resulted in the production sperms of poor quality very similar to that observed in the monkeys. Blockade of FSH function achieved by immunization of monkeys with a recombinant oFSH receptor protein fragment also resulted in effects identical to that observed in oFSH immunized monkey and man. Hitherto, the oFSH vaccine has not shown any symptoms of overt toxicity as tested in rats, monkeys and to limited extent in man.
It is concluded that extension of these studies with recombinant oFSHβ and oFSH receptor protein fragment is urgently needed to further validate our claim that male contraception is achievable by FSH vaccine development.p
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Moudgal, N.R., Dighe, R.R. (1999). Is FSH Based Contraceptive Vaccine a Feasible Proposition for the Human Male?. In: Gupta, S.K. (eds) Reproductive Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4197-0_36
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DOI: https://doi.org/10.1007/978-94-011-4197-0_36
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