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Reproductive Immunology

  • Satish K. Gupta

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Molecular and Immunological Aspects of Sperm-Oocyte Interaction

  3. Embryonic-Endometrial Cross-Talk

  4. Immunobiology of Pregnancy

    1. Lalji Singh, N. H. Pathak, A. J. Rachel, K. Thangaraj
      Pages 132-148
    2. R. Raghupathy, M. Makhseed, F. Azizieh, M. M. K. Al-Azemi, N. A. Hassan, A. Bandar
      Pages 149-158
    3. Michelle Letarte
      Pages 167-178
    4. J. F. Mowbray, J. L. Underwood
      Pages 179-186
    5. I. L. Sargent, G. P. Sacks, M. Knight, A. Kr. Smarason, C. W. G. Redman
      Pages 198-204
    6. Howard Carp, Arkady Torchinsky, Vladimir Toder
      Pages 205-217
    7. Julia Szekeres-Bartho, A. Barakonyi, B. Polgar, G. Par, Zs. Faust, T. Palkovics et al.
      Pages 218-223
    8. Philippe Le Bouteiller, Valérie Mallet
      Pages 224-232
    9. Peeyush K. Lala, Milan Zdravkovic, George Aboagye-Mathiesen, Marie-Josée Guimond
      Pages 233-241
  5. Autoantibodies and Infertility

    1. Franco Dondero, Loredana Gandini, Francesco Lombardo, Antonio Filippini, Paola Lauretti, Elio Ziparo et al.
      Pages 242-255
  6. Immunocontraception

    1. G. P. Talwar
      Pages 277-284
    2. Kenneth W. Beagley, Nicole Newcombe, Zhong Ling Wu, Christine M. Gockel, Shisian Bao, Michael J. Holland et al.
      Pages 285-293
    3. Kenneth S. K. Tung, Yahuan Lou, Harini Bagavant
      Pages 303-308
    4. Erwin Goldberg, John C. Herr
      Pages 309-315
    5. Umashashi C. Hegde, Kamala Gopalkrishnan, Vrinda Khole, Deepa Bhartiya
      Pages 316-333
    6. S. B. Moodbidri, G. R. Vanage, P. B. Mehta, K. S. N. Iyer
      Pages 358-365
  7. Mucosal Immunology and Reproductive Tract Infection

    1. Alison J. Quayle, Florina Haimovici, Deborah J. Anderson
      Pages 379-386
    2. Fumitaka Saji, Yoshihiro Samejima, Shoji Kamiura, Koichiro Shimoya, Masayasu Koyama, Tadashi Kimura
      Pages 387-394
  8. Back Matter
    Pages 395-401

About this book

Introduction

Reproductive Immunology is a compilation of research articles presented during the VII International Congress of Reproductive Immunology which was held in New Delhi, India on 27-30 October 1998. The articles pertain to the following six major themes:
  1. Molecular and Immunological Aspects of Sperm-Egg Interaction
  2. Embryonic-Endometrial Cross-Talk
  3. Immunobiology of Pregnancy
  4. Autoantibodies and Infertility
  5. Immunocontraception
  6. Mucosal Immunology and Reproductive Tract Infections
.
The first section deals with our current understanding of various steps involved in fertilization. The functional significance of sperm surface mannosidase and glutathione S-transferases to bind zona pellucida is described. The role of zona pellucida glycoproteins in the binding of sperm, induction of acrosome reactions and avoidance of polyspermy is discussed. In the second section, the role of various cytokines, growth factors and immunomodulatory agents in implantation of embryos is described. In the field of reproductive immunology, one of the major issues is to explore the successful gestation of the histoincompatible fetus in the uterus of an immunologically competent mother. The Proceedings presents the issues of paternal antigens at the feto-maternal interface and shows that Th2-type of immunity is involved in normal successful conception. The role of membrane-bound and soluble HLA-G in protecting the fetus from the lytic activities of maternal uterine and peripheral blood natural killer (NK) cells is also presented.
Nature's experiments suggest that antibodies against sperm-specific antigens are responsible for infertility in some women. The possibility that an immunogenetic background contributes to production of sperm-immobilizing antibodies in infertile women is discussed in the section on autoantibodies and infertility. The Proceedings presents the issue of Th1-type cytokines in inducing recurrent spontaneous abortions of unexplained etiology. The roles of β2-glycoprotein 1 (β2-GP1)-dependent anticardiolipin antibody, lupus anticoagulant, antiphospholipids, anti-thyroid antibody and anti-nuclear antibody in miscarriages are also described.
The rising global human population, particularly in the developing countries, has driven the need for new and safer methods of contraception. Fertility regulation by vaccines is thus an interesting proposition. The section on contraceptive vaccines discusses the latest advances in this area and describes the current status of vaccines based on βhCG, sperm antigens, zona pellucida glycoproteins, and riboflavin carrier proteins.
The issues of mucosal immunity and strategies for enhancing local genital immune responses to combat HIV infection is discussed. The role of inflammatory and related cytokines in chorioamnionitis is described.
The contents of this Proceedings describes various facets of reproductive immunology which will help us to design strategies to combat genital infections and miscarriages caused by immunological etiology. Descriptions of the molecular basis of gamete recognition, implantation and survival of the allogenic fetus will help in designing strategies for overcoming infertility and also new contraceptive approaches. The Proceedings will be useful to researchers and clinicians involved in basic or applied research in the disciplines of reproductive biology, reproductive immunology, and obstetrics and gynecology.

Keywords

Antigen HIV immunobiology infections infertility

Editors and affiliations

  • Satish K. Gupta
    • 1
  1. 1.Gamete Antigen LaboratoryNational Institute of ImmunologyNew DelhiIndia

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-011-4197-0
  • Copyright Information Springer Science+Business Media Dordrecht 1999
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-5825-4
  • Online ISBN 978-94-011-4197-0
  • Buy this book on publisher's site
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