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The genetics of nuclear pre-mRNA splicing: a complex story

  • Chapter
Molecular Biology of Saccharomyces

Abstract

The occurrence of introns in nuclear precursor RNAs (pre-mRNAs) is widespread in eukaryotes, and the splicing process that removes them is basically the same in yeasts as it is in higher eukaryotes. Splicing takes place in a very large, multi-component complex, the spliceosome, and biochemical studies have been complicated by the large number of splicing factors involved. This review describes how genetic approaches used to study RNA splicing in Saccharomyces cerevisiae have complemented the biochemical studies and led to rapid advances in the field.

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Author information

Authors and Affiliations

  1. Institute of Cell and Molecular Biology, University of Edinburgh, King’s Buildings, Mayfield Road, Edinburgh, EH9 3JR, Scotland

    Jeremy D. Brown, Mary Plumpton & Jean D. Beggs

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  1. Jeremy D. Brown
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  2. Mary Plumpton
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  3. Jean D. Beggs
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Editors and Affiliations

  1. Molecular Biology Section, University of Amsterdam, The Netherlands

    L. A. Grivell

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© 1992 Springer Science+Business Media Dordrecht

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Brown, J.D., Plumpton, M., Beggs, J.D. (1992). The genetics of nuclear pre-mRNA splicing: a complex story. In: Grivell, L.A. (eds) Molecular Biology of Saccharomyces . Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2504-8_4

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  • DOI: https://doi.org/10.1007/978-94-011-2504-8_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5104-0

  • Online ISBN: 978-94-011-2504-8

  • eBook Packages: Springer Book Archive

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