Molecular Biology of Saccharomyces

1. Front Matter

   Pages i-1

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2. Nuclear transport and nuclear pores in yeast

   • U. Nehrbass, E. C. Hurt

   Pages 3-14

3. Topoisomerase II: its functions and phosphorylation

   • Susan M. Gasser, Robin Walter, Qi Dang, Maria E. Cardenas

   Pages 15-24

4. Global regulators of chromosome function in yeast

   • John F. X. Diffley

   Pages 25-33

5. The genetics of nuclear pre-mRNA splicing: a complex story

   • Jeremy D. Brown, Mary Plumpton, Jean D. Beggs

   Pages 35-46

6. Molecular biology of translation in yeast

   • Patrick Linder

   Pages 47-62

7. Peroxisome biogenesis in Saccharomyces cerevisiae

   • Wolf H. Kunau, Andreas Hartig

   Pages 63-78

8. Heterologous protein production in yeast

   • Gerd Gellissen, Karl Melber, Zbigniew A. Janowicz, Ulrike M. Dahlems, Ulrike Weydemann, Michael Piontek et al.

   Pages 79-93

9. The pheromone signal pathway in Saccharomyces cerevisiae

   • James B. Konopka, Stanley Fields

   Pages 95-108

10. The RAS-adenylate cyclase pathway and cell cycle control in Saccharomyces cerevisiae

    • Johan M. Thevelein

    Pages 109-130

11. Genetic approaches to the study of mitochondrial biogenesis in yeast

    • M. Bolotin-Fukuhara, L. A. Grivell

    Pages 131-153

At a fundamental research level, the yeasts offer valuable opportunities for modelling regulatory and metabolic processes in multicellular eukaryotic organisms: this volume deals with the multifunctional chromosome regulatory proteins, topoisomerase and nuclear transport. A combination of biochemical and genetic approaches applied to the yeast translation system is also currently yielding a wealth of data, while the mating pheromone signal transduction pathway in yeasts provides a valuable analogue of the signal transduction components used by multicellular organisms, including receptors, G proteins, protein kinases and transcription factors.
With a well-established history of fermantation studies, yeasts remain the first-choice vehicle for production of heterologous eukaryotic proteins. Interest is diversifying, as an increasing number of non-Saccharomyces species are now being utilised for the production of specific heterologous proteins.
Molecular biologists, microbiologists and biochemical geneticists will find this volume an authoritative and valuable update on a vibrant area of research.

• biology
• molecular biology
• protein
• proteins
• receptor
• signal transduction
• transcription
• translation

• Molecular Biology Section, University of Amsterdam, The Netherlands

  L. A. Grivell

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