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Drug discovery

  • Chapter
Principles of Molecular Recognition

Abstract

For over a decade now, the major players in the pharmaceutical league have had at their disposal an array of modern tools to assist in the discovery of new drugs; ample time one would think for the products of such research to move through the various stages of clinical evaluation and on to the market. These tools include computerised QSAR analyses, high resolution NMR spectroscopy, vastly improved X-ray crystallographic methods, molecular modelling and the power of molecular biology. In addition, an often undervalued, and sometimes derided tool, is the ability to systematically search the ‘chemical universe’ and screen representative molecules from each sector against new biological assays. In order to judge the impact of these modern techniques, it is interesting to compare the discoveries of the last 25 years with those recently emerged from the secret vaults of the top-ranked companies. This is the focus of this chapter.

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  1. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

    A. D. Buckingham

  2. Department of Chemistry, University of Exeter, Stocker Road, Exeter, EX4 4QD, UK

    A. C. Legon  & S. M. Roberts  & 

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Saunders, J. (1993). Drug discovery. In: Buckingham, A.D., Legon, A.C., Roberts, S.M. (eds) Principles of Molecular Recognition. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2168-2_6

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