Principles of Molecular Recognition

  • A. D. Buckingham
  • A. C. Legon
  • S. M. Roberts

Table of contents

  1. Front Matter
    Pages i-xi
  2. A. D. Buckingham
    Pages 1-16
  3. A. C. Legon, D. J. Millen
    Pages 17-42
  4. J. M. Brown, P. J. Guiry, A. Wienand
    Pages 79-107
  5. J. Saunders
    Pages 137-167
  6. L. A. Findsen, S. Subramanian, V. Lounnas, B. M. Pettitt
    Pages 168-193
  7. Back Matter
    Pages 195-200

About this book

Introduction

The importance of molecular recognition in chemistry and biology is reflected in a recent upsurge in relevant research, promoted in particular by high-profile initiatives in this area in Europe, the USA and Japan. Although molecular recognition is necessarily microscopic in origin, its consequences are de facto macroscopic. Accordingly, a text that starts with intermolecular interactions between simple molecules and builds to a discussion of molecular recognition involving larger scale systems is timely. This book was planned with such a development in mind. The book begins with an elementary but rigorous account of the various types of forces between molecules. Chapter 2 is concerned with the hydrogen bond between pairs of simple molecules in the gas phase, with particular reference to the preferred relative orientation of the pair and the ease with which this can be distorted. This microscopic view continues in chapter 3 wherein the nature of interactions between solute molecules and solvents or between two or more solutes is examined from the experimental standpoint, with various types of spectroscopy providing the probe of the nature of the interactions. Molecular recognition is central to the catalysis of chemical reactions, especially when bonds are to be broken and formed under the severe con­ straint that a specific configuration is to result, as in the production of enan­ tiotopically pure compounds. This important topic is considered in chapter 4.

Keywords

bonding drug design dynamics enzyme enzymes metals molecule nuclear magnetic resonance phase protein receptor spectroscopy synthesis ultraviolet

Editors and affiliations

  • A. D. Buckingham
    • 1
  • A. C. Legon
    • 2
  • S. M. Roberts
    • 2
  1. 1.Department of ChemistryUniversity of CambridgeCambridgeUK
  2. 2.Department of ChemistryUniversity of ExeterExeterUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-011-2168-2
  • Copyright Information Chapman & Hall 1993
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-4959-7
  • Online ISBN 978-94-011-2168-2
  • About this book
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