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Genetic Variation and Nutrition

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Genetic factors in coronary heart disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 156))

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Abstract

The role of nutrition in coronary heart disease (CHD) is a complex one. Its understanding is continuously evolving. Evidence that dietary intake directly affects CHD is hard to come by. One reason is that most of the impact of dietary variation on the extent of coronary atherosclerosis probably arises from the effects of the former on blood lipids, primary low density lipoprotein (LDL) cholesterol1. Another issue is the extreme intra-individual variation in dietary intake, which may often exceed interindividual variation and may obscure a true association between diet and coronary risk factors2 so that very low correlations are obtained in cross-sectional studies3 unless multiple dietary assessment takes place. A number of long-term prospective studies were, however, able to demonstrate sizeable differences in coronary morbidity or mortality between individuals who vary in the intake of polyunsaturated fatty acids4, saturated fat4, dietary cholesterol5 or fish6, 7. Quantitatively higher correlations have been derived previously from ‘ecological’ comparisons, suggesting that the mean intake of dietary saturated fat is directly related, and those of poly- and monounsaturated fat inversely related, to rates of fatal CHD across populations8, 9. The better-known findings of this nature have been reported from the landmark Seven Countries Study by Keys et al.9. The estimated mean intakes of nutrients in large groups are not hampered by the large intra-individual variability that plays havoc with within-population relationships.

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Authors and Affiliations

  1. Section of Epidemiology and Biostatistics, Henry N. Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer, 52621, Israel

    Uri Goldbourt

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  1. Uri Goldbourt
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Editors and Affiliations

  1. Sackler Medical Faculty, Epidemiology and Biostatistics, the Neufeld Cardiac Research Institute, Sheba Medical Center and Tel Aviv University, Israel

    Uri Goldbourt (Professor of Epidemiology and Preventive Medicine, Head) (Professor of Epidemiology and Preventive Medicine, Head)

  2. Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden

    Ulf de Faire (Professor) (Professor)

  3. Institute of Medical Genetics, Department of Medical Genetics, Ullevål University Hospital, Oslo, Norway

    KÃ¥re Berg (Professor of Medicine, Chairman, Director and Physician-in-Chief) (Professor of Medicine, Chairman, Director and Physician-in-Chief)

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© 1994 Springer Science+Business Media Dordrecht

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Goldbourt, U. (1994). Genetic Variation and Nutrition. In: Goldbourt, U., de Faire, U., Berg, K. (eds) Genetic factors in coronary heart disease. Developments in Cardiovascular Medicine, vol 156. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1130-0_28

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  • DOI: https://doi.org/10.1007/978-94-011-1130-0_28

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4494-3

  • Online ISBN: 978-94-011-1130-0

  • eBook Packages: Springer Book Archive

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