Skip to main content
SpringerLink
Log in
Book cover

Genetic factors in coronary heart disease

  • Book
  • © 1994

Overview

Editors:
  1. Uri Goldbourt

    1. Sackler Medical Faculty, Epidemiology and Biostatistics, the Neufeld Cardiac Research Institute, Sheba Medical Center and Tel Aviv University, Israel

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Ulf Faire

    1. Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Kåre Berg

    1. Institute of Medical Genetics, Department of Medical Genetics, Ullevål University Hospital, Oslo, Norway

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 156)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (30 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  3. Coronary heart disease risk factors and their genetics

    1. Front Matter

      Pages 69-69
      Download chapter PDF

    2. Assessing Genetic and Cultural Heritabilities

      • D. C. Rao, George P. Vogler
      Pages 71-81

    3. Lipids, Apolipoproteins and Lipoproteins

      • Daniel J. Rader, H. Bryan Brewer Jr.
      Pages 83-103

    4. Low Density Lipoprotein Subclass Phenotypes

      • Melissa A. Austin
      Pages 105-113

    5. Rabbit Models in Genetic Research in Atherosclerosis

      • Masashi Shiomi, Yoshio Watanabe
      Pages 115-124

    6. Fibrinogen, Factor VII, and Plasminogen Activator Inhibitor-1

      • William P. Fay, David Ginsburg
      Pages 125-138

    7. Homocysteine

      • Killian Robinson, Kok Soon Tan, Ian M. Graham
      Pages 139-152

    8. Blood Pressure Variation

      • Clarence E. Grim, Miguel T. Robinson
      Pages 153-177

    9. Rat Models for Atherosclerosis

      • Yukio Yamori
      Pages 179-187

    10. Human Obesities

      • Claude Bouchard
      Pages 189-202

    11. Diabetes and Insulin Resistance

      • Leslie J. Raffel, Tamar Shohat, Jerome I. Rotter
      Pages 203-215

    12. Smoking and Sports Participation

      • Judith R. Koopmans, Lorenz J. P. van Doornen, Dorret I. Boomsma
      Pages 217-235

  4. Monogenic traits affecting coronary heart disease incidence

    1. Front Matter

      Pages 237-237
      Download chapter PDF

    2. Genetic Defects in Lipoprotein Metabolism

      • Gustav Schonfeld, Elaine S. Krul
      Pages 239-266
Back to top

Keywords

About this book

Incidence and mortality of atherosclerosis and coronary heart disease (CHD) vary considerably among races, populations and ethnic groups. Some individuals with low levels of risk factors succumb early to disease while many others with a high risk profile do not. CHD clusters in families and is manyfold increased in first degree relatives of persons with an early onset of the disease. Such studies provide compelling evidence of the high degree of heritability of CHD and its risk factors.
This book consolidates the available evidence for the roles of genetics in atherosclerosis, its correlates and its sequelae. It presents and discusses the methodology currently used to elucidate the role of genetics. Separate parts focus on evidence of familial aggregation and ethnic variability of the disease and on monogenic and polygenic inheritance modes including all the recent findings and innovation. The book also contains chapters on the genetic aspects of vessel wall processes, such as early structural findings in histological studies and the variability of coronary anatomic patterns. Polymorphisms at the DNA level (RFLP) are detailed and reviewed. Directions for future research in the exciting and fast developing realm of genetic epidemiology are outlined and the major preventive and public health implications are discussed.
Genetic Factors in Coronary Heart Disease provides a systematic review of findings, integrated to offer a comprehensive summary and stepping stone for future research. It will be of interest to investigators in atherosclerosis, genetics, epidemiology, biostatistics, cardiology and public health.

Editors and Affiliations

  • Sackler Medical Faculty, Epidemiology and Biostatistics, the Neufeld Cardiac Research Institute, Sheba Medical Center and Tel Aviv University, Israel

    Uri Goldbourt

  • Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden

    Ulf Faire

  • Institute of Medical Genetics, Department of Medical Genetics, Ullevål University Hospital, Oslo, Norway

    Kåre Berg

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation