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Normal Polymorphism at the Low Density Lipoprotein Receptor (LDLR) Locus: Effect on Cholesterol Levels and Interaction with Apolipoprotein E (apoE) Genes

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Genetic factors in coronary heart disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 156))

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Abstract

Family, twin and population studies have uncovered significant effects of genes on levels of risk factors or protective factors with respect to coronary heart disease (CHD)1,2 and it is an important task to uncover the individual genes contributing to risk-factor heritability. Current attempts to identify such genes follow the ‘candidate gene’ approach1–5. Among the candidate genes with respect to coronary heart disease (CHD), the apolipoprotein genes have been the focus of much research. Candidate gene studies conducted at the level of LDL allotypes or apolipoprotein E isoforms before DNA technology became available uncovered effects of normal genes at the apolipoprotein B (apoB) and apolipoprotein E (apoE) loci on lipid levels. With the advent of DNA technology, the potential for studies employing the candidate gene approach was dramatically expanded and numerous studies on restriction fragment length polymorphisms (RFLPs) at apolipoprotein loci and risk factor levels or overt disease have been reported.

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Authors and Affiliations

  1. Department of Medical Genetics, Ullevål Hospital, P.O. Box 1036, Blindem, N-0135, Oslo 3, Norway

    Jan Chr. Pedersen & Kåre Berg

Authors
  1. Jan Chr. Pedersen
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  2. Kåre Berg
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Editor information

Editors and Affiliations

  1. Sackler Medical Faculty, Epidemiology and Biostatistics, the Neufeld Cardiac Research Institute, Sheba Medical Center and Tel Aviv University, Israel

    Uri Goldbourt (Professor of Epidemiology and Preventive Medicine, Head) (Professor of Epidemiology and Preventive Medicine, Head)

  2. Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden

    Ulf de Faire (Professor) (Professor)

  3. Institute of Medical Genetics, Department of Medical Genetics, Ullevål University Hospital, Oslo, Norway

    Kåre Berg (Professor of Medicine, Chairman, Director and Physician-in-Chief) (Professor of Medicine, Chairman, Director and Physician-in-Chief)

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© 1994 Springer Science+Business Media Dordrecht

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Pedersen, J.C., Berg, K. (1994). Normal Polymorphism at the Low Density Lipoprotein Receptor (LDLR) Locus: Effect on Cholesterol Levels and Interaction with Apolipoprotein E (apoE) Genes. In: Goldbourt, U., de Faire, U., Berg, K. (eds) Genetic factors in coronary heart disease. Developments in Cardiovascular Medicine, vol 156. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1130-0_22

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  • DOI: https://doi.org/10.1007/978-94-011-1130-0_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4494-3

  • Online ISBN: 978-94-011-1130-0

  • eBook Packages: Springer Book Archive

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