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Blood Pressure Variation

  • Chapter
Genetic factors in coronary heart disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 156))

Abstract

The level of blood pressure is a function of: (1) the genetically dictated physiological control systems that regulate blood pressure, and (2) the interaction of these genotypes with the known environmental factors that modulate the blood pressure level: psychosocial stress and/or excessive intake of calories, sodium and alcohol. Because it is not possible to elevate the blood pressure without altering the renal handling of sodium2, any cause of high blood pressure must ultimately mediate its effects through the kidney as the final regulator of body fluid volume. The physiological control systems that regulate sodium and volume, and therefore blood pressure, are crucial to the survival of man under adverse conditions of heat and limited access to salt and water. It seems likely that the ability to conserve sodium has led to differential mortality (selective survival) in those groups best able to conserve sodium3 and may account for both between- and within-population variations in susceptibility to the blood pressure raising effects of salt. Because high blood pressure is a sign of a disturbance of one or more of the blood pressure control systems, genetic investigation of subjects just classified as ‘hypertensive’ will probably be confusing until specific physiological subgroups of hypertensives are studied. Kurtz et al. have published two excellent reviews of the new genetic approaches in animal4 and human5 studies in hypertension and the Williams group at Utah have also published excellent reviews6. Much of the data presented here is not in these reviews.

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Authors and Affiliations

  1. Hypertension Research, Charles R. Drew University, 1621 E. 120th St., Los Angeles, CA, 90059, USA

    Clarence E. Grim & Miguel T. Robinson

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  1. Clarence E. Grim
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  2. Miguel T. Robinson
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Editors and Affiliations

  1. Sackler Medical Faculty, Epidemiology and Biostatistics, the Neufeld Cardiac Research Institute, Sheba Medical Center and Tel Aviv University, Israel

    Uri Goldbourt (Professor of Epidemiology and Preventive Medicine, Head) (Professor of Epidemiology and Preventive Medicine, Head)

  2. Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden

    Ulf de Faire (Professor) (Professor)

  3. Institute of Medical Genetics, Department of Medical Genetics, Ullevål University Hospital, Oslo, Norway

    Kåre Berg (Professor of Medicine, Chairman, Director and Physician-in-Chief) (Professor of Medicine, Chairman, Director and Physician-in-Chief)

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© 1994 Springer Science+Business Media Dordrecht

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Grim, C.E., Robinson, M.T. (1994). Blood Pressure Variation. In: Goldbourt, U., de Faire, U., Berg, K. (eds) Genetic factors in coronary heart disease. Developments in Cardiovascular Medicine, vol 156. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1130-0_11

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  • DOI: https://doi.org/10.1007/978-94-011-1130-0_11

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