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The Extracellular Calcium-Sensing Receptor: Molecular Features, Distribution and Its Role in Physiology and Disease

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Calcium: The Molecular Basis of Calcium Action in Biology and Medicine

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Abstract

Extracellular Ca2+ levels in blood and other biological fluids can be sensed by cells of the Ca2+ homeostatic system that possess a G protein-coupled receptor (GPR) known as the extracellular calcium-sensing receptor (CaR). The discovery that extracellular Ca2+ (Ca 2+0 ) can invoke intracellular signaling responses similarly to GPR agonists such as epinephrine and vasopressin, has revealed that, in addition to being a fundamental intracellular second messenger, Ca2+ also represents an important extracellular “first” messenger in its own right.

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  1. School of Biological Sciences, University of Manchester, Manchester, UK

    Donald T. Ward & Daniela Riccardi

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  1. Donald T. Ward
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  2. Daniela Riccardi
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  1. Université Libre de Bruxelles, Belgium

    Roland Pochet

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Ward, D.T., Riccardi, D. (2000). The Extracellular Calcium-Sensing Receptor: Molecular Features, Distribution and Its Role in Physiology and Disease. In: Pochet, R., Donato, R., Haiech, J., Heizmann, C., Gerke, V. (eds) Calcium: The Molecular Basis of Calcium Action in Biology and Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0688-0_10

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  • DOI: https://doi.org/10.1007/978-94-010-0688-0_10

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