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Calcium: The Molecular Basis of Calcium Action in Biology and Medicine

  • Roland Pochet
  • Rosario Donato
  • Jacques Haiech
  • Claus Heizmann
  • Volker Gerke

Table of contents

  1. Front Matter
    Pages i-xxxix
  2. From Genes to Drugs

    1. Jacques Haiech, Marcel Hibert
      Pages 1-6
  3. Basic Mechanisms of Action of Calcium

    1. Front Matter
      Pages 7-7
    2. Calcium Signalling in Excitable Cells

      1. Nathalie Macrez, Jean Mironneau
        Pages 9-25
      2. S. J. Marsh, N. Wanaverbecq, A. A. Selyanko, D. A. Brown
        Pages 27-44
    3. Calcium Signalling in Non-Excitable Cells

      1. J. W. M. Heemskerk
        Pages 45-71
      2. Greg J. Barritt
        Pages 73-94
      3. Thierry Tordjmann, Caroline Clair, Michel Claret, Laurent Combettes
        Pages 95-108
      4. Karl-Heinz Braunewell, Carsten Reissner, Eckart D. Gundefinger
        Pages 129-149
    4. Calcium Signalling in Extracellular Matrix

    5. Calcium Storage and Release

      1. Jan B. Parys, Ilse Sienaert, Sara Vanlingen, Geert Callewaert, Patrick De Smet, Ludwig Missiaen et al.
        Pages 179-190
      2. Marek Michalak, Kimitoshi Nakamura, Sylvia Papp, Michal Opas
        Pages 191-204
      3. Daniela Rossi, Virginia Barone, Ilenia Simeoni, Vincenzo Sorrentino
        Pages 205-219
      4. Hozumi Kawamichi, Akio Nakamura, Kazuhiro Kohama
        Pages 221-244
    6. Calcium and Apoptosis

    7. Calcium and Cellular Ageing

      1. Alexej Verkhratsky, Emil Toescu
        Pages 277-286
    8. Calcium and Growth Factor

      1. Antonio Villalobo, María José Ruano, Paloma I. Palomo-Jiménez, Hongbing Li, José Martín-Nieto
        Pages 287-303
  4. Calcium Related Diseases

    1. Front Matter
      Pages 305-305
    2. Harvey B. Pollard, Meera Srivastava
      Pages 307-316
    3. P. Eggleton, D. H. Llewellyn
      Pages 317-331
    4. P. A. van Zwieten
      Pages 333-363
    5. Rudolf Valenta, Anna Twardosz, Ines Swoboda, Brigitte Hayek, Susanne Spitzauer, Dietrich Kraft
      Pages 365-377
    6. Daniela Pietrobon
      Pages 379-400
    7. Shahidul Islam
      Pages 401-413
    8. Edward M. Brown, Naibedya Chattopadhyay, Mei Bai
      Pages 415-442
    9. Yasuko Ono, Shoji Hata, Hiroyuki Sorimachi, Koichi Suzuki
      Pages 443-464
    10. Fernando Rodríguez de Fonseca, Miguel Angel Gorriti, Miguel Navarro
      Pages 465-476
    11. Gerry Hagens, Georges Siegenthaler
      Pages 477-492
    12. Cancer

      1. Ricardo L. Gee, Lalita Subramanian, Teresa M. Walker, Paul R. van Ginkel, Arthur S. Polans
        Pages 493-504
      2. Patrizia Paterlini-Bréchot, Mounia Chami, Devrim Gozuacik
        Pages 505-519
      3. Kelly Y. Chun, David B. Sacks
        Pages 541-563
    13. Liver Diseases

      1. Keiko Kobayashi, Mikio Iijima, Tomotsugu Yasuda, David S. Sinasac, Naoki Yamaguchi, Lap-Chee Tsui et al.
        Pages 565-587
    14. Neurodegeneration

    15. Neurodegenerative Diseases

  5. Methodological Chapters

    1. Front Matter
      Pages 639-639
    2. Jacques Haiech, Jean-Luc Galzi, Marcel Hibert
      Pages 641-646
    3. Vincent J. Dupriez
      Pages 647-659
    4. Calcium Imaging, Flourence Microscopy, Confocal Microscopy

  6. Back Matter
    Pages 715-732

About this book

Introduction

The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world.
The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era.
The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets.
In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches. Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists.
The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.

Keywords

Calcium G proteins cells growth factor microscopy molecular mechanisms neurons platelets proteins

Editors and affiliations

  • Roland Pochet
    • 1
  • Rosario Donato
  • Jacques Haiech
  • Claus Heizmann
  • Volker Gerke
  1. 1.Université Libre de BruxellesBelgium

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