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Chromosomal Radiosensitivity as an Indicator of Genetic Predisposition to Breast Cancer

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Some Aspects of Chromosome Structure and Functions

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Abstract

An abnormally high frequency of chromatid breaks, representing unrepaired DNA double-strand breaks, in cells entering metaphase 30 to 90 min after irradiation, is a good indicator of the donor's predisposition to breast cancer. The unrepaired DNA double-strand breaks resulting from deficient repair of the radiation-induced DNA damage are evident in non cancerous cells like skin fibroblasts or blood lymphocytes from breast cancer patients carrying predisposing genes, with familial and some sporadic cancer partients and individuals at a risk to develop cancer. Such deficiency to repair DNA double-strand breaks resulting in persistent chromatid breaks, at least twofold higher than normal, after G2 phase X-irradiation may therefore be used as a marker of cancer susceptibility in cancer families.

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Author notes

  1. Katherine K. Sanford

    Present address: , 101, Sturat Drive, Dover, DE, 19001

Authors and Affiliations

  1. Department of Pathology, Howard University Collage of Medicine, Washington, D.C., 20059, USA

    Ram Parshad

  2. Laboratory Cellular and Molecular Biology, National Cancer Institute, National Institute of Health, Bethesda, MD, 20892, USA

    Katherine K. Sanford

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  1. Ram Parshad
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  2. Katherine K. Sanford
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Editors and Affiliations

  1. Department of Biotechnology, Panjab University, Chandigarh, India

    R. C. Sobit

  2. Institute of Genetics, University of Essen, Universitaetsstrasse 5, D-45117, Essen, Germany

    G. Obe

  3. Department of Pathology and Laboratory Medicine Pels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine Philadelphia, USA

    R. S. Athwal

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© 2002 Narosa Publishing House, New Delhi, India

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Parshad, R., Sanford, K.K. (2002). Chromosomal Radiosensitivity as an Indicator of Genetic Predisposition to Breast Cancer. In: Sobit, R.C., Obe, G., Athwal, R.S. (eds) Some Aspects of Chromosome Structure and Functions. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0334-6_16

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  • DOI: https://doi.org/10.1007/978-94-010-0334-6_16

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