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NF-кB in the Vascular System

  • Chapter
Nuclear Factor кB

  • 126 Accesses

Abstract

From the contributions up to now it should have become very clear that NF-кB plays a central role in diverse aspects of innate and adaptive immune and, more generally, stress-response reactions. In this regard, the vascular wall that represents one of the main barriers in the organism, namely the interface between blood and underlying tissue, is of outstanding importance. The vascular wall consists mainly of endothelial cells (EC) and smooth muscle cells (SMC) and, not unexpectedly, NF-кB has multiple functions in these cells. NF-кB deregulation is not only associated, but in many instances functionally involved in a variety of vascular disorders; it is the purpose of this chapter to discuss some of them in more detail.

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Authors and Affiliations

  1. Department of Vascular Biology and Thrombosis Research, University of Vienna, Brunnerstraße 59, 1235, Vienna, Austria

    R. De Martin

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  1. R. De Martin
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  1. Department for Molecular Biomedical Research, Unit for Molecular Signal Transduction in Inflammation, Ghent University and Flanders Interuniversity Institute for Biotechnology, K.L. Ledeganckstraat 35, 9000, Ghent, Belgium

    Rudi Beyaert

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© 2003 Springer Science+Business Media Dordrecht

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De Martin, R. (2003). NF-кB in the Vascular System. In: Beyaert, R. (eds) Nuclear Factor кB. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0163-2_15

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  • DOI: https://doi.org/10.1007/978-94-010-0163-2_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3983-3

  • Online ISBN: 978-94-010-0163-2

  • eBook Packages: Springer Book Archive

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