Advertisement

Nuclear Factor кB

Regulation and Role in Disease

  • Rudi Beyaert

Table of contents

  1. Front Matter
    Pages i-xi
  2. I. Carpentier, S. Janssens, K. Heyninck, R. Beyaert
    Pages 49-67
  3. J.-L. Poyet, E. S. Alnemri
    Pages 69-88
  4. T. D. Gilmore, G. Mosialos
    Pages 89-113
  5. U. Senftleben, M. Karin
    Pages 115-135
  6. L. Deng, Z. J. Chen
    Pages 137-158
  7. A. O’Mahony, L. F. Chen, W. C. Greene
    Pages 159-176
  8. T. Huxford, G. Ghosh
    Pages 177-198
  9. Y. Yamamoto, U. N. Verma, R. B. Gaynor
    Pages 199-219
  10. K. De Bosscher, W. Vanden Berghe, G. Haegeman
    Pages 221-239
  11. N. Suzuki, M. Bonnard, S. Suzuki, W.-C Yeh
    Pages 265-294
  12. E. Andreakos, I. Udalova, S. Sacre, B. M. Foxwell
    Pages 295-323
  13. G. Courtois, A. Israël
    Pages 325-334
  14. R. De Martin
    Pages 335-351
  15. O. Dienz, S. Bacher, M. L. Schmitz
    Pages 353-371
  16. B. Kaltschmidt, C. Kaltschmidt
    Pages 373-392
  17. Back Matter
    Pages 423-426

About this book

Introduction

Seventeen years after its initial description, nuclear factor-KB (NF-KB) endures as one of the most studied transcription factors. NF-KB has attracted widespread interest based on the variety of stimuli that activate it, the diverse genes and bio­ logical responses that it controls, the striking evolutionary conservation of struc­ ture and function among species, and its involvement in a variety of human diseases. The biochemical basis by which several stimuli converge to activate NF-KB has been largely elucidated during recent years. While first discovered as a key regulatory factor of the immune system, NF-KB is now recognized as an important player in the functioning of many organs and cell types. The ongoing examination of NF-KB signaling has revealed its ever expanding role in immune and inflammatory responses, but also in cancer and development. For this reason, numerous efforts are underway to develop safe inhibitors of NF-KB to be used in the treatment of both chronic and acute disease situations. The present book is the first to review and synthesize our knowledge of this interesting transcription factor. As such, the choice of subjects to review was daunting. To set the stage, an introductory chapter on activators and target genes, as well as the role they play in several responses, has been included.

Keywords

Mammalia apoptosis biology biomedicine cell cell biology cellular differentiation diseases inflammation nervous system oncogene phosphorylation protein structural biology transcription

Editors and affiliations

  • Rudi Beyaert
    • 1
  1. 1.Department for Molecular Biomedical Research, Unit for Molecular Signal Transduction in InflammationGhent University and Flanders Interuniversity Institute for BiotechnologyGhentBelgium

Bibliographic information

Industry Sectors
Pharma
Biotechnology
Consumer Packaged Goods