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Titin as a modular spring: emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology

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Mechanics of Elastic Biomolecules

Abstract

Titin is a giant elastic protein that functions as a molecular spring that develops passive muscle stiffness. Here we discuss the molecular basis of titin’s extensibility, how titin’s contribution to passive muscle stiffness may be adjusted and how adjustment of titin’s stiffness may influence muscle contraction. We also focus on ligands that link titin to membrane channel activity, protein turnover and gene expression.

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Authors and Affiliations

  1. Department VCAPP, Washington State University, Pullman, WA, 99164-6520, USA

    Henk Granzier & Yiming Wu

  2. Anesthesiology and Intensive Operative Medicine, University Hospital Mannheim, 68135, Germany

    Dietmar Labeit & Siegfried Labeit

Authors
  1. Henk Granzier
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  2. Dietmar Labeit
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  3. Yiming Wu
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  4. Siegfried Labeit
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Correspondence to Henk Granzier .

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Editors and Affiliations

  1. University of Heidelberg, Heidelberg, Germany

    Wolfgang A. Linke

  2. Washington State University, Pullman, WA, USA

    Henk Granzier

  3. University of Pécs, Pécs, Hungary

    Miklós S. Z. Kellermayer

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Granzier, H., Labeit, D., Wu, Y., Labeit, S. (2003). Titin as a modular spring: emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology. In: Linke, W.A., Granzier, H., Kellermayer, M.S.Z. (eds) Mechanics of Elastic Biomolecules. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0147-2_7

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  • DOI: https://doi.org/10.1007/978-94-010-0147-2_7

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