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Mechanics and imaging of single DNA molecules

  • Chapter
Mechanics of Elastic Biomolecules

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Abstract

We review recent experiments that have revealed mechanical properties of single DNA molecules using advanced manipulation and force sensing techniques (scanning force microscopy (SFM), optical or magnetic tweezers, microneedles). From such measurements, intrinsic relevant parameters (persistence length, stretch modulus) as well as their dependence on external parameters (non-physiological conditions, coating with binding agents or proteins) are obtained on a single-molecule level. In addition, imaging of DNA molecules using SFM is presented.

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Authors and Affiliations

  1. Institute of Physics, NCCR Nanoscale Science, University of Basel, Klingelbergstrasse 82, CH-4056, Basel, Switzerland

    M. Hegner & W. Grange

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  1. M. Hegner
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  2. W. Grange
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Editors and Affiliations

  1. University of Heidelberg, Heidelberg, Germany

    Wolfgang A. Linke

  2. Washington State University, Pullman, WA, USA

    Henk Granzier

  3. University of Pécs, Pécs, Hungary

    Miklós S. Z. Kellermayer

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Hegner, M., Grange, W. (2003). Mechanics and imaging of single DNA molecules. In: Linke, W.A., Granzier, H., Kellermayer, M.S.Z. (eds) Mechanics of Elastic Biomolecules. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0147-2_1

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  • DOI: https://doi.org/10.1007/978-94-010-0147-2_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3971-0

  • Online ISBN: 978-94-010-0147-2

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