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Properties of the Fast Sodium Channel and of the Muscarinic Receptor during Development of Embryonic Heart Cells in Ovo and in Vitro

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Cardiac Rate and Rhythm

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 17))

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Abstract

During ontogenesis of the chick embryonic heart (and also of the mammalian heart) two important properties of the excitable membrane which play a role in the regulation of the rate of the pacemaker system appear to follow a drastic differentiation. These two properties are the physiological expression of the fast Na+ channel inhibitable by tetrodotoxin and the negative inotrope effect due to the interaction of acetylcholine with its muscarinic receptor.

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Authors
  1. Michel Lazdunksi
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  2. Jean-Francois Renaud
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  3. Georges Romey
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  4. Michel Fosset
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  5. Jacques Barhanin
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  6. Alain Lombet
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Editors and Affiliations

  1. Department of Physiology, University of Amsterdam, The Netherlands

    Lennart N. Bouman  & Habo J. Jongsma  & 

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© 1982 Martinus Nijhoff Publishers, The Hague

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Lazdunksi, M., Renaud, JF., Romey, G., Fosset, M., Barhanin, J., Lombet, A. (1982). Properties of the Fast Sodium Channel and of the Muscarinic Receptor during Development of Embryonic Heart Cells in Ovo and in Vitro. In: Bouman, L.N., Jongsma, H.J. (eds) Cardiac Rate and Rhythm. Developments in Cardiovascular Medicine, vol 17. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7535-4_30

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  • DOI: https://doi.org/10.1007/978-94-009-7535-4_30

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7537-8

  • Online ISBN: 978-94-009-7535-4

  • eBook Packages: Springer Book Archive

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