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Cardiac Rate and Rhythm

Physiological, Morphological and Developmental Aspects

  • Book
  • © 1982

Overview

Editors:
  1. Lennart N. Bouman

    1. Department of Physiology, University of Amsterdam, The Netherlands

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    You can also search for this editor in PubMed   Google Scholar

  2. Habo J. Jongsma

    1. Department of Physiology, University of Amsterdam, The Netherlands

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 17)

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Table of contents (31 chapters)

  1. Front Matter

    Pages I-XIV
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  2. Introduction

    1. Introduction

      • Lennart N. Bouman, Habo J. Jongsma
      Pages 1-3

  3. Fundamentals of Pacemaker Activity

    1. Front Matter

      Pages 5-5
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    2. Pacemaker Mechanisms

      • Paul F. Cranefield
      Pages 7-17

    3. On the Ultrastructural Identification of Pacemaker Cell Types within the Sinus Node

      • Mireille Masson-Pevet, Wim K. Bleeker, Elly Besselsen, Albert J. C. Mackaay, Habo J. Jongsma, Lennart N. Bouman
      Pages 19-34

    4. Pacemaker Mechanisms of Rabbit Sinoatrial Node Cells

      • Hiroshi Irisawa, Akinori Noma
      Pages 35-51

    5. The Relative Contributions of Various Time-Dependent Membrane Currents to Pacemaker Activity in the Sino Atrial Node

      • Hilary Brown, Junko Kimura, Susan Noble
      Pages 53-68

    6. The Current IK2 in Purkinje Fibres Reinterpreted and Identified with the Current IF in the SA Node

      • Dario DiFrancesco
      Pages 69-91

    7. Implications of the Re-Interpretation of iK2 for the Modelling of the Electrical Activity of Pacemaker Tissues in the Heart

      • Dario DiFrancesco, Denis Noble
      Pages 93-128

    8. Pacemaker Mechanisms in Myocardial Cells during Development of Embryonic Chick Hearts

      • Nick Sperelakis
      Pages 129-165

  4. Interaction of Pacemaker Cells

    1. Front Matter

      Pages 167-168
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    2. Cellular Communication: Introductory Remarks

      • Silvio Weidmann
      Pages 169-177

    3. On the Control of Cell Communication in Heart

      • Walmor C. De Mello
      Pages 179-194

    4. Electrical Cell Coupling in Rabbit Sino Atrial Node and Atrium Experimental and Theoretical Evaluation

      • Feliksas F. Bukauskas, Aron M. Gutman, Klemensas J. Kisunas, Romualdas P. Veteikis
      Pages 195-216

    5. Gap Junction Structure in Coupled and Uncoupled Conditions

      • Camillo Peracchia
      Pages 217-242

    6. Formation and Growth of Myocardial Gap Junctions: In Vivo and In Vitro Studies

      • Daniel Gros, Ian Lee, Cyril E. Challice
      Pages 243-264

    7. Intercellular Coupling between Embryonic Heart Cell Aggregates

      • David E. Clapham, Robert L. DeHaan
      Pages 265-281

    8. Intercellular Coupling between Cardiac Cells and its Disturbances

      • Jacek Wojtczak
      Pages 283-296

    9. Ectopic Activity in the Early Phase of Regional Myocardial Ischemia

      • Michiel J. Janse, Frans J. L. van Capelle
      Pages 297-320

  5. Establishment of Cardiac Rhythm

    1. Front Matter

      Pages 321-321
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Keywords

About this book

In the denervated state the mammalian heart, both in vivo and in vitro, is excited at very regular intervals, the coefficient of variance of the interbeat intervals not exceeding 2%. The pacemaker that is the source of this regular ex­ citation is localised normally within the sinus node (" sino-atrial node " node of Keith and Flack), a most intriguing small piece of tissue in the caval corner of the right atrium. A small portion of this node containing a group of probably only a few thousands of cells fires spontaneously, that means without any exter­ nal influence to trigger their activity. The so called pacemaker cells do this by letting their membrane potential fall to the level where an action potential will start which subsequently activates surrounding cells to fire an action po­ tential. The first question which is tackled in this book is which processes underly this spontaneous diastolic depolarization. This is discussed in section I, concerning the fundamental properties of pacemaker cells with special refer­ ence to ionic membrane currents. Although views still quite differ about the exact nature of the membrane processes that cause the automatic pacemaker dis­ charge there is agreement that diastolic depolarization is brought about by the interaction of a number of ionic current systems, including both inward and out­ ward going currents.

Editors and Affiliations

  • Department of Physiology, University of Amsterdam, The Netherlands

    Lennart N. Bouman, Habo J. Jongsma

Bibliographic Information

  • Book Title: Cardiac Rate and Rhythm

  • Book Subtitle: Physiological, Morphological and Developmental Aspects

  • Editors: Lennart N. Bouman, Habo J. Jongsma

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-94-009-7535-4

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Martinus Nijhoff Publishers, The Hague 1982

  • Hardcover ISBN: 978-90-247-2626-4Due: 30 April 1982

  • Softcover ISBN: 978-94-009-7537-8Published: 12 October 2011

  • eBook ISBN: 978-94-009-7535-4Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: 696

  • Topics: Cardiology

  • Industry Sectors: Biotechnology, Engineering, Finance, Business & Banking, Health & Hospitals, Pharma

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