Electrical Cell Coupling in Rabbit Sino Atrial Node and Atrium Experimental and Theoretical Evaluation

  • Feliksas F. Bukauskas
  • Aron M. Gutman
  • Klemensas J. Kisunas
  • Romualdas P. Veteikis
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 17)

Abstract

Intercellular coupling has hitherto been scrutinized nearly in every myocardial structure and at many phylogenetic levels, the human heart being not excepted (Barr, 1969; Bonke, 1973; Bredikis et al., 1976, 1978; Bukauskas et al., 1977a, 1977b; De Mello, 1977; Johnson and Tille, 1961; Sakson et al., 1974; Seyama, 1976; Tanaka and Sasaki, 1966; Weidmann, 1970). The most popular approach in cell to cell coupling studies has been the measurement of passive electrical properties, viz. input resistance and space constant of electrotonic decay. To evaluate these parameters with regard to cell coupling theoretical models are needed which simulate the passive electrical properties and which take into account the actual build up of myocardial tissue as good as possible.

Keywords

Anisotropy Manifold Radium CaCl2 Pyruvate 

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References

  1. Barr, L.: Electrical transmission between the cells of vertebrate cardiac muscle. In: Comparative Physiology of the Heart: Current Trends. McCann, F.V., ed., Birkenhauser Verlag, Basel and Stuttgart, pp. 102–110, 1969.Google Scholar
  2. Bleeker, W.K., Mackaay, A.J.C., Masson-Pevet, M., Bouman, L.N. and Becker, A.E.: Functional and morphological organization of the rabbit sinus node. Circ. Res., 46: 11–22, 1980.PubMedGoogle Scholar
  3. Bonke, F.I.M.: Electrotonic spread in the sinoatrial node of the rabbit heart. Pfluegers Arch., 339: 17–23, 1973.CrossRefGoogle Scholar
  4. Bredikis, J.J., Bukauskas, F.F., Muckus, K.S. and Puodzius, S.S.: Ontogenetic pecularities of the electrical activity in cardiac fibres of human embryo. J. Evol. Biochem. Physiol. (Leningrad), 14: 43–48, 1978.Google Scholar
  5. Bukauskas, F.F., Kukushkin, N.I. and Saxon, M.E.: Model of two-dimensional anisotropic syncitium. Biofizika, 19: 712–716, 1974.PubMedGoogle Scholar
  6. Bukauskas, F.F. and Veteikis, R.P.: Passive electrical properties of AV node region of rabbits heart. Biofizika, 22: 449–504, 1977a.Google Scholar
  7. Bukauskas, F.F., Veteikis, R.P. and Gutman, A.M.: A model for passive three-dimensional anisotropic syncitium as continuous medium. Biofizika, 20: 1083–1086, 1975.PubMedGoogle Scholar
  8. Bukauskas, F.F., Veteikis, R.P., Gutman, A.M. and Mutskus, K.S.: Intercellular electrical coupling in the sinoatrial node of rabbit’s heart. Biofizika, 22: 108–112, 1977b.PubMedGoogle Scholar
  9. Cranefield, P.F. and Greenspan, K.: The rate of oxygen uptake of quiescent cardiac muscle. J. Gen. Physiol., 44: 235–247, 1961.CrossRefGoogle Scholar
  10. De Mello, W.C.: Passive electrical properties of the atrioventricular node. Pfluegers Arch., 371: 135–139, 1977.CrossRefGoogle Scholar
  11. Hodgkin, A.L. and Rushton, W.A.H.: The electrical constants of a crustacean nerve fibre. Proc. Roy. Soc. London, B133: 444–479, 1946.Google Scholar
  12. Hoffman, B.F.: Atrioventricular conduction in mammalian hearts. Ann. N.Y. Acad. Sci., 127: 105–112, 1965.PubMedCrossRefGoogle Scholar
  13. Johnson, E.A. and Tille, J.: Investigations of the electrical properties of cardiac muscle fibres with the aid of intracellular double-barrelled electrodes. J. Gen. Physiol., 44: 443–467, 1961.PubMedCrossRefGoogle Scholar
  14. Kukushkin, N.I., Bukauskas, F.F. and Saxon, M.E.: II. Model of two-dimensional anisotropic syncitium. Biofizika, 19: 888–893, 1974.Google Scholar
  15. Masson-Pevet, M.A.: The fine structure of cardiac pacemaker cells in the sinus node and in tissue culture. (Doct. Thesis), Rodopi, Amsterdam, 1979.Google Scholar
  16. Masuda, M.O. and Paes de Carvalho, A.: Sinoatrial transmission and atrial invasion during normal rhythm in the rabbit heart. Circ. Res., 37: 414–421, 1975.PubMedGoogle Scholar
  17. Matter, A.: A morphometric study on the nexus of rat cardiac muscle. J. Cell Biol., 56: 690–696, 1973.PubMedCrossRefGoogle Scholar
  18. Pearson, O.H., Hastings, A.B. and Bunting, H.: Metabolism of cardiac muscle: utilization of C14 labelled pyruvate and acetate by heart slices. Amer. J. Physiol., 158: 251–260, 1949.PubMedGoogle Scholar
  19. Purves, R.D.: Current flow and potential in a three-dimensional syncitium. J. Theor. Biol., 60: 147–163, 1976.PubMedCrossRefGoogle Scholar
  20. Sakson, M.E., Bukauskas, F.F., Kukushkin, N.I. and Nasonova, V.V.: Study of electrotonic distribution on the surface of cardiac structures. Biofizika, 19: 1045–1049, 1974.PubMedGoogle Scholar
  21. Sano, T. and Iida, Y.: Sinoatrial connection and wandering pacemaker. J. Electrocardiol., 1: 147–153, 1968.PubMedCrossRefGoogle Scholar
  22. Sano, T. and Yamagishi, S.: Spread of excitation from the sinus node. Circ. Res., 16: 423–430, 1965.PubMedGoogle Scholar
  23. Sano, T., Yamagishi, S. and Iida, Y.: Several aspects on the spontaneous activity of the sinus node and its spread. Jap. Circ. J., 30: 134–138, 1966.PubMedCrossRefGoogle Scholar
  24. Schanne, O.F.: Measurement of cytoplasmic resistivity by means of the glass microelectrodes. In: Glass microelectrodes, Lavallee, M., Schanne, O.F. and Herbert, N.C., eds., Wiley Sons, New York-London-Sydney-Toronto, pp. 299–321, 1969.Google Scholar
  25. Seyama, I.: Characteristics of the rectifying properties of the sino-atrial node cell of the rabbit. J. Physiol. (London), 255: 379–397, 1976.Google Scholar
  26. Smolyaninov, V.V.: Mathematical models of biological tissues (in Russian), Nauka, Moscow, 1980.Google Scholar
  27. Sperelakis, N. and Macdonald, R.L.: Ratio of transverse to longitudinal resistivities of isolated cardiac muscle fiber bundle. J. Electrocardiol., 7: 301–314, 1974.PubMedCrossRefGoogle Scholar
  28. Strauss, H.C. and Bigger, J.T.: Electrophysiologic properties of the rabbit sinoatrial perinodal fibers. Circ. Res., 31: 490–506, 1972.PubMedGoogle Scholar
  29. Tanaka, I. and Sasaki, Y.: On the electrotonic spread in cardiac muscle of the mouse. J. Gen. Physiol., 49: 1089–1110, 1966.PubMedGoogle Scholar
  30. Trautwein, W. and Uchizono, K.: Electron microscopic and electrophysiologic study of the pacemaker in the sinoatrial node of the rabbit heart. Z. Zellforsch., 61: 96–109, 1963.PubMedCrossRefGoogle Scholar
  31. Weidmann, S.: Electrical constants of trabecular muscle from mammalian heart. J. Physiol. (London), 210: 1041–1054, 1970.Google Scholar

Copyright information

© Martinus Nijhoff Publishers, The Hague 1982

Authors and Affiliations

  • Feliksas F. Bukauskas
  • Aron M. Gutman
  • Klemensas J. Kisunas
  • Romualdas P. Veteikis

There are no affiliations available

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