Abstract
Metastatic spread and growth are the most crucial manifestations of malignancy in human cancer. If tumors were nonmetastatic their surgical removal would effect complete recovery. Unfortunately, surgical excision of the malignant tumor in many patients does not prevent the metastatic growth in different anatomic locations and therefore death. In experiments it was found that the excision of the transplanted tumor in mice may render mice immune to a subsequent graft of the same tumor cells [1, 2]. By using murine metastasizing tumors it was found that the surgical exision of the primary tumor was accompanied by accelerated growth of pulmonary metastases. Tyzzer [3] and Tadenuma and Okogoni [4] were the first to describe this puzzling phenomenon. Further, using inbred strains of mice and syngeneic tumors, Schatten [5] and Ketcham et al. [6] confirmed this observation.
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© 1982 Martinus Nijhoff Publishers, The Hague/Boston/London
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Gorelik, E. (1982). Antimetastatic concomitant immunity. In: Liotta, L.A., Hart, I.R. (eds) Tumor Invasion and Metastasis. Developments in Oncology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7511-8_8
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DOI: https://doi.org/10.1007/978-94-009-7511-8_8
Publisher Name: Springer, Dordrecht
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