Tumor Invasion and Metastasis

1. Front Matter

   Pages I-X

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2. Tumor-Host Interactions in Metastasis

   1. The role of animal models in the study of experimental metastasis

      • I. R. Hart

      Pages 1-14

   2. Eradication of metastases by tumoricidal macrophages: therapeutic implications

      • I. J. Fidler

      Pages 15-27

   3. The role of natural killer (NK) cells in the control of tumor metastasis

      • N. Hanna

      Pages 29-41

   4. Metastasis of xenogeneic and allogeneic tumors in nude mice

      • N. Hanna

      Pages 43-55

   5. Cell surface properties of metastatic tumor cells

      • G. L. Nicolson

      Pages 57-79

   6. Metastatic inefficiency

      • L. Weiss

      Pages 81-98

   7. Tumor cell Chemotaxis

      • J. Varani, P. A. Ward

      Pages 99-112

   8. Antimetastatic concomitant immunity

      • E. Gorelik

      Pages 113-131

   9. Immunobiological diversity of metastatic cells

      • E. Gorelik, M. Fogel, P. De Baetselier, S. Katzav, M. Feldman, S. Segal

      Pages 133-146

3. Models of Tumor Invasion

   1. Methods and models for studying tumor invasion

      • G. Poste

      Pages 147-171

   2. In vitro quantitative assay of invasion using human amnion

      • R. G. Russo, U. Thorgeirsson, L. A. Liotta

      Pages 173-187

   3. Experimental models of lymphatic metastasis

      • I. Carr, J. Carr

      Pages 189-205

   4. The use of embryo organ cultures to study invasion in vitro

      • M. M. K. Mareel

      Pages 207-230

   5. Three-dimensional models for the study of invasion and metastasis

      • H. Gershman

      Pages 231-250

   6. In vitro assay of invasion using endothelial and smooth muscle cells

      • P. A. Jones

      Pages 251-266

   7. The regulation of invasion by a cartilage-derived anti-invasion factor

      • B. U. Pauli, K. E. Kuettner

      Pages 267-290

4. Interaction of Tumor Cells with Connective Tissue

   1. Role of cell attachment proteins in defining cell-matrix interactions

      • H. K. Kleinman

      Pages 291-308

   2. Attachment of metastatic tumor cells to collagen

      • J. C. Murray, L. A. Liotta, V. P. Terranova

      Pages 309-318

   3. Biochemical mechanisms involved in tumor cell penetration of the basement membrane

      • L. A. Liotta, S. Garbisa, K. Tryggvason

      Pages 319-333

The clinical significance of tumor spread has always been appreciated. Yet, in spite of the pioneering work and outstanding contributions of investigators such as D. Coman, H. Green, B. Fisher, S. Wood and I. Zeidman, studies on metastasis rarely achieved the popularity afforded to more esoteric areas of tumor biology. Tumor dissemination, occurring as it does in a responding host and being composed of a series of dynamic int~ractions, is a highly complex phenomenon. Few investigators were brave enough to attempt to unravel the mechanisms involved. Paradoxically, this very complexity may have contributed, in part, to the recent upsurge of interest in metastasis research. More and more researchers are becoming fascinated by the complexities of the cellular interactions involved in tumor spread. Accompanying this intellectual stimulation have been technological advances in related fields which allow the derivation of new model systems. The mechanisms of metastatic spread are increasingly amenable to both the reductionist and holistic approaches and it is the purpose of this volume to present many of these model systems while emphasizing the intricacy and complexity of the processes they mimic. We have attempted to emphasize two topics not previously covered in depth in previous books on metastases. These are in vitro models of invasion and in­ teractions of tumor cells with connective tissue.

• metastasis
• tumor

• National Cancer Institute, Bethesda, USA

  L. A. Liotta

• Frederick Cancer Research Center, Frederick, USA

  I. R. Hart

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