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Cell surface properties of metastatic tumor cells

  • Chapter
Tumor Invasion and Metastasis

Part of the book series: Developments in Oncology ((DION,volume 7))

Abstract

Since the interaction of tumor cells with their environment is mediated by cell surface constituents, this structure is thought to play one of the most important roles in metastasis. Modifications in cell surface properties have been described in detail and compared in particular, between transformed cells and their untransfor- med counterparts. In these systems modifications at the cell surface have generally correlated with neoplastic transformation (see reviews by Hynes [1], Nicolson [2] and Roblin et al. [3]); however, few of these changes are probably relevant to metastasis [2, 4]. Using the animal model systems described elsewhere in this volume (Chapter 1), it has been possible to examine in detail cell surface properties and their potential involvement in metastasis.

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Authors
  1. G. L. Nicolson
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Editors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland, USA

    L. A. Liotta

  2. Frederick Cancer Research Center, Frederick, Maryland, USA

    I. R. Hart

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© 1982 Martinus Nijhoff Publishers, The Hague/Boston/London

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Nicolson, G.L. (1982). Cell surface properties of metastatic tumor cells. In: Liotta, L.A., Hart, I.R. (eds) Tumor Invasion and Metastasis. Developments in Oncology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7511-8_5

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  • DOI: https://doi.org/10.1007/978-94-009-7511-8_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7513-2

  • Online ISBN: 978-94-009-7511-8

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