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Tumor formation and malignant invasion: role of basal lamina

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Tumor Invasion and Metastasis

Part of the book series: Developments in Oncology ((DION,volume 7))

Abstract

Carcinoma is by far the most commonly occurring form of cancer and is a neoplasm of epithelial cell origin. In any neoplasm, local invasion and metastasis are the two most reliable criteria that designate the tumor as malignant. Direct invasion is the first and most crucial step in the malignant process and is defined in carcinomata by local disruption of basal lamina with tumor cell infiltration info the underlying connective tissue space (Figure 1).

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Authors
  1. D. E. Ingber
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  2. J. D. Jamieson
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Editors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland, USA

    L. A. Liotta

  2. Frederick Cancer Research Center, Frederick, Maryland, USA

    I. R. Hart

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© 1982 Martinus Nijhoff Publishers, The Hague/Boston/London

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Ingber, D.E., Jamieson, J.D. (1982). Tumor formation and malignant invasion: role of basal lamina. In: Liotta, L.A., Hart, I.R. (eds) Tumor Invasion and Metastasis. Developments in Oncology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7511-8_20

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  • DOI: https://doi.org/10.1007/978-94-009-7511-8_20

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